Niclosamide Prevents the Formation of Large Ubiquitin-Containing Aggregates Caused by Proteasome Inhibition

BACKGROUND: Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly targets short-lived proteins, or by the lysosomes...

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Detalles Bibliográficos
Autores principales: Gies, Esther, Wilde, Inga, Winget, Jason M., Brack, Maria, Rotblat, Barak, Novoa, Carolina Arias, Balgi, Aruna D., Sorensen, Poul H., Roberge, Michel, Mayor, Thibault
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009716/
https://www.ncbi.nlm.nih.gov/pubmed/21203451
http://dx.doi.org/10.1371/journal.pone.0014410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009716/
https://www.ncbi.nlm.nih.gov/pubmed/21203451
http://dx.doi.org/10.1371/journal.pone.0014410

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