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Muscle weakness in Ryr1(I4895T/WT) knock-in mice as a result of reduced ryanodine receptor Ca(2+) ion permeation and release from the sarcoplasmic reticulum

The type 1 isoform of the ryanodine receptor (RYR1) is the Ca(2+) release channel of the sarcoplasmic reticulum (SR) that is activated during skeletal muscle excitation–contraction (EC) coupling. Mutations in the RYR1 gene cause several rare inherited skeletal muscle disorders, including malignant h...

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Detalles Bibliográficos
Autores principales:	Loy, Ryan E., Orynbayev, Murat, Xu, Le, Andronache, Zoita, Apostol, Simona, Zvaritch, Elena, MacLennan, David H., Meissner, Gerhard, Melzer, Werner, Dirksen, Robert T.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010056/ https://www.ncbi.nlm.nih.gov/pubmed/21149547 http://dx.doi.org/10.1085/jgp.201010523

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