Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteoblast maturation, thereby causing bone loss in Runx2 transgenic mice. Zinc finger protein 521 (Zfp521) antagonizes Runx2 in vivo. Eliminating one Zfp521 allele mitigates the cleidocranial dysplasi...

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Detalles Bibliográficos
Autores principales: Hesse, Eric, Saito, Hiroaki, Kiviranta, Riku, Correa, Diego, Yamana, Kei, Neff, Lynn, Toben, Daniel, Duda, Georg, Atfi, Azeddine, Geoffroy, Valérie, Horne, William C., Baron, Roland
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010073/
https://www.ncbi.nlm.nih.gov/pubmed/21173110
http://dx.doi.org/10.1083/jcb.201009107

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