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mRNA turnover rate limits siRNA and microRNA efficacy
The microRNA pathway participates in basic cellular processes and its discovery has enabled the development of si/shRNAs as powerful investigational tools and potential therapeutics. Based on a simple kinetic model of the mRNA life cycle, we hypothesized that mRNAs with high turnover rates may be mo...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
European Molecular Biology Organization
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010119/ https://www.ncbi.nlm.nih.gov/pubmed/21081925 http://dx.doi.org/10.1038/msb.2010.89 |