Human AP-endonuclease (APE1/Ref-1) and its acetylation regulate YB-1/p300 recruitment and RNA polymerase II loading in the drug induced activation of multidrug resistance gene MDR1

Overexpression of human AP-endonuclease (APE1/Ref-1), a key enzyme in the DNA base excision repair (BER) pathway, is often associated with tumor cell resistance to various anticancer drugs. In this study, we examined the molecular basis of transcriptional regulatory (non repair) function of APE1 in...

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Detalles Bibliográficos
Autores principales: Sengupta, Shiladitya, Mantha, Anil K., Mitra, Sankar, Bhakat, Kishor K.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010319/
https://www.ncbi.nlm.nih.gov/pubmed/20856196
http://dx.doi.org/10.1038/onc.2010.435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010319/
https://www.ncbi.nlm.nih.gov/pubmed/20856196
http://dx.doi.org/10.1038/onc.2010.435

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