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Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet
Background. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subse...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010702/ https://www.ncbi.nlm.nih.gov/pubmed/21197152 http://dx.doi.org/10.1155/2011/959601 |
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author | Kullberg, Joel Sundbom, Magnus Haenni, Arvo Freden, Susanne Johansson, Lars Börnert, Peter Ahlström, Anders Ahlström, Håkan Karlsson, Anders |
author_facet | Kullberg, Joel Sundbom, Magnus Haenni, Arvo Freden, Susanne Johansson, Lars Börnert, Peter Ahlström, Anders Ahlström, Håkan Karlsson, Anders |
author_sort | Kullberg, Joel |
collection | PubMed |
description | Background. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods. 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results. Body weight was similarly reduced after both months (mean: −8.0 kg, n = 13). Relative body fat changes were smaller after LCD than after GBP (−7.1 ± 3.6% versus −10 ± 3.2%, P = .029, n = 13). Liver fat fell during the LCD month (−41%, P = .001, n = 13) but was unaltered one month after GBP (+12%). Conclusion. Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed. |
format | Text |
id | pubmed-3010702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30107022010-12-30 Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet Kullberg, Joel Sundbom, Magnus Haenni, Arvo Freden, Susanne Johansson, Lars Börnert, Peter Ahlström, Anders Ahlström, Håkan Karlsson, Anders J Obes Research Article Background. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods. 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results. Body weight was similarly reduced after both months (mean: −8.0 kg, n = 13). Relative body fat changes were smaller after LCD than after GBP (−7.1 ± 3.6% versus −10 ± 3.2%, P = .029, n = 13). Liver fat fell during the LCD month (−41%, P = .001, n = 13) but was unaltered one month after GBP (+12%). Conclusion. Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed. Hindawi Publishing Corporation 2011 2010-12-21 /pmc/articles/PMC3010702/ /pubmed/21197152 http://dx.doi.org/10.1155/2011/959601 Text en Copyright © 2011 Joel Kullberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kullberg, Joel Sundbom, Magnus Haenni, Arvo Freden, Susanne Johansson, Lars Börnert, Peter Ahlström, Anders Ahlström, Håkan Karlsson, Anders Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
title | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
title_full | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
title_fullStr | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
title_full_unstemmed | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
title_short | Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet |
title_sort | gastric bypass promotes more lipid mobilization than a similar weight loss induced by low-calorie diet |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010702/ https://www.ncbi.nlm.nih.gov/pubmed/21197152 http://dx.doi.org/10.1155/2011/959601 |
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