Atopic Dermatitis-Like Skin Lesions Reduced by Topical Application and Intraperitoneal Injection of Hirsutenone in NC/Nga Mice

Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical ap...

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Detalles Bibliográficos
Autores principales: Jeong, Mi Sook, Choi, Sun Eun, Kim, Ji Young, Kim, Jung Shim, Kim, Eun Joo, Park, Kwan Hee, Lee, Do Ik, Joo, Seong Soo, Lee, Chung Soo, Bang, Hyoweon, Lee, Mi-Kyung, Choi, Young Wook, Li, Kap-sok, Moon, Nam Ju, Lee, Min Won, Seo, Seong Jun
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010703/
https://www.ncbi.nlm.nih.gov/pubmed/21197410
http://dx.doi.org/10.1155/2010/618517
Descripción
Sumario:Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this paper Th2-related cytokines (IL-4, IL-5, IL-13), eosinophil, IgE inflammatory factors (COX-2, iNOS) levels were reduced in blood, lymphocytes, and tissue after HIR treatment. These results suggest that HIR might be an effective treatment for AD.

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