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Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women
We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactive...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010706/ https://www.ncbi.nlm.nih.gov/pubmed/21197412 http://dx.doi.org/10.4061/2011/904878 |
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author | Matvienko, O. A. Alekel, D. L. Bhupathiraju, S. N. Hofmann, H. Ritland, L. M. Reddy, M. B. Van Loan, M. D. Perry, C. D. |
author_facet | Matvienko, O. A. Alekel, D. L. Bhupathiraju, S. N. Hofmann, H. Ritland, L. M. Reddy, M. B. Van Loan, M. D. Perry, C. D. |
author_sort | Matvienko, O. A. |
collection | PubMed |
description | We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactive protein, fibrinogen, and homocysteine. We collected data on 224 healthy postmenopausal women at risk for osteoporosis (45.8–65 y, median BMI 24.5) who consumed placebo or soy isoflavones (80 or 120 mg/d) for 36 months and used longitudinal analysis to examine the contribution of isoflavone treatment, androidal fat mass, other biologic factors, and dietary quality to cardiometabolic outcomes. Except for homocysteine, each cardiometabolic outcome model was significant (overall P-values from ≤.0001 to .0028). Androidal fat mass was typically the strongest covariate in each model. Isoflavone treatment did not influence any of the outcomes. Thus, androidal fat mass, but not isoflavonetreatment, is likely to alter the cardiometabolic profile in healthy postmenopausal women. |
format | Text |
id | pubmed-3010706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-30107062010-12-30 Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women Matvienko, O. A. Alekel, D. L. Bhupathiraju, S. N. Hofmann, H. Ritland, L. M. Reddy, M. B. Van Loan, M. D. Perry, C. D. Cardiol Res Pract Research Article We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactive protein, fibrinogen, and homocysteine. We collected data on 224 healthy postmenopausal women at risk for osteoporosis (45.8–65 y, median BMI 24.5) who consumed placebo or soy isoflavones (80 or 120 mg/d) for 36 months and used longitudinal analysis to examine the contribution of isoflavone treatment, androidal fat mass, other biologic factors, and dietary quality to cardiometabolic outcomes. Except for homocysteine, each cardiometabolic outcome model was significant (overall P-values from ≤.0001 to .0028). Androidal fat mass was typically the strongest covariate in each model. Isoflavone treatment did not influence any of the outcomes. Thus, androidal fat mass, but not isoflavonetreatment, is likely to alter the cardiometabolic profile in healthy postmenopausal women. SAGE-Hindawi Access to Research 2010-12-19 /pmc/articles/PMC3010706/ /pubmed/21197412 http://dx.doi.org/10.4061/2011/904878 Text en Copyright © 2011 O. A. Matvienko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Matvienko, O. A. Alekel, D. L. Bhupathiraju, S. N. Hofmann, H. Ritland, L. M. Reddy, M. B. Van Loan, M. D. Perry, C. D. Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
title | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
title_full | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
title_fullStr | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
title_full_unstemmed | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
title_short | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
title_sort | androidal fat dominates in predicting cardiometabolic risk in postmenopausal women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010706/ https://www.ncbi.nlm.nih.gov/pubmed/21197412 http://dx.doi.org/10.4061/2011/904878 |
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