Pegylated IFN-α sensitizes melanoma cells to chemotherapy and causes premature senescence in endothelial cells by IRF-1-mediated signaling

Pegylated interferon-α2b (pIFN-α) is an integral part of the drug regimen currently employed against melanoma. Interferon regulatory factor-1 (IRF-1) has an important role in the transcriptional regulation of the IFN response, cell cycle and apoptosis. We have studied pIFN-α-induced responses when c...

Descripción completa

Detalles Bibliográficos
Autores principales: Upreti, M, Koonce, N A, Hennings, L, Chambers, T C, Griffin, R J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010727/
https://www.ncbi.nlm.nih.gov/pubmed/21197417
http://dx.doi.org/10.1038/cddis.2010.43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010727/
https://www.ncbi.nlm.nih.gov/pubmed/21197417
http://dx.doi.org/10.1038/cddis.2010.43

Ejemplares similares