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RENAL FUNCTION AFTER LONG TERM TREATMENT WITH LITHIUM
Renal functions of 30 patients of manic depressive psychosis on long term lithium prophylaxis have been studied and compared with 15 age and sex matched patients receiving psychotropic drugs other than lithium. The urine output more than 2.5 L/day was seen in 12 patients (4(1% ) while impaired capac...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
1988
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010817/ https://www.ncbi.nlm.nih.gov/pubmed/21927287 |
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author | Dhar, M.K. Bhatia, M.S. Agrawal, Pradeep Khurana, S.K. Bohra, Neena Malik, S.C. |
author_facet | Dhar, M.K. Bhatia, M.S. Agrawal, Pradeep Khurana, S.K. Bohra, Neena Malik, S.C. |
author_sort | Dhar, M.K. |
collection | PubMed |
description | Renal functions of 30 patients of manic depressive psychosis on long term lithium prophylaxis have been studied and compared with 15 age and sex matched patients receiving psychotropic drugs other than lithium. The urine output more than 2.5 L/day was seen in 12 patients (4(1% ) while impaired capacity to show urinary osmolality more than 500 m Osm/L after overnight fluid deprivation was seen in 6 patients. Creatinine clearance ranged between 70-106 ml/min (mean 89 ml/mt). Creatinine clearance less than 70 ml/nun was seen in 3 patients. The ratio of urinary and serum creatinine showed statistically significant (p< .001) low value in lithium treated group. There was also significant increase in mean uric acid excretion in patients on lithium therapy. It is recommended that inspite of serum lithium levels being in normal range, renal functions should be assessed regularly in order to avoid progressive impairment of renal functions. |
format | Text |
id | pubmed-3010817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1988 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-30108172011-09-16 RENAL FUNCTION AFTER LONG TERM TREATMENT WITH LITHIUM Dhar, M.K. Bhatia, M.S. Agrawal, Pradeep Khurana, S.K. Bohra, Neena Malik, S.C. Indian J Psychiatry Original Article Renal functions of 30 patients of manic depressive psychosis on long term lithium prophylaxis have been studied and compared with 15 age and sex matched patients receiving psychotropic drugs other than lithium. The urine output more than 2.5 L/day was seen in 12 patients (4(1% ) while impaired capacity to show urinary osmolality more than 500 m Osm/L after overnight fluid deprivation was seen in 6 patients. Creatinine clearance ranged between 70-106 ml/min (mean 89 ml/mt). Creatinine clearance less than 70 ml/nun was seen in 3 patients. The ratio of urinary and serum creatinine showed statistically significant (p< .001) low value in lithium treated group. There was also significant increase in mean uric acid excretion in patients on lithium therapy. It is recommended that inspite of serum lithium levels being in normal range, renal functions should be assessed regularly in order to avoid progressive impairment of renal functions. Medknow Publications 1988 /pmc/articles/PMC3010817/ /pubmed/21927287 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dhar, M.K. Bhatia, M.S. Agrawal, Pradeep Khurana, S.K. Bohra, Neena Malik, S.C. RENAL FUNCTION AFTER LONG TERM TREATMENT WITH LITHIUM |
title | RENAL FUNCTION AFTER LONG TERM TREATMENT WITH LITHIUM |
title_full | RENAL FUNCTION AFTER LONG TERM TREATMENT WITH LITHIUM |
title_fullStr | RENAL FUNCTION AFTER LONG TERM TREATMENT WITH LITHIUM |
title_full_unstemmed | RENAL FUNCTION AFTER LONG TERM TREATMENT WITH LITHIUM |
title_short | RENAL FUNCTION AFTER LONG TERM TREATMENT WITH LITHIUM |
title_sort | renal function after long term treatment with lithium |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010817/ https://www.ncbi.nlm.nih.gov/pubmed/21927287 |
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