Formation and Toxicity of Soluble Polyglutamine Oligomers in Living Cells

BACKGROUND: Aggregation and cytotoxicity of mutant proteins containing an expanded number of polyglutamine (polyQ) repeats is a hallmark of several diseases, including Huntington's disease (HD). Within cells, mutant Huntingtin (mHtt) and other polyglutamine expansion mutant proteins exist as mo...

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Detalles Bibliográficos
Autores principales: Lajoie, Patrick, Snapp, Erik Lee
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011017/
https://www.ncbi.nlm.nih.gov/pubmed/21209946
http://dx.doi.org/10.1371/journal.pone.0015245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011017/
https://www.ncbi.nlm.nih.gov/pubmed/21209946
http://dx.doi.org/10.1371/journal.pone.0015245

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