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Formation and Toxicity of Soluble Polyglutamine Oligomers in Living Cells
BACKGROUND: Aggregation and cytotoxicity of mutant proteins containing an expanded number of polyglutamine (polyQ) repeats is a hallmark of several diseases, including Huntington's disease (HD). Within cells, mutant Huntingtin (mHtt) and other polyglutamine expansion mutant proteins exist as mo...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011017/ https://www.ncbi.nlm.nih.gov/pubmed/21209946 http://dx.doi.org/10.1371/journal.pone.0015245 |