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Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient

BACKGROUND: Mucormycosis is a rare, aggressive fungal disease with high mortality, typically presenting as rhinosinusitis in immunocompromised patients. CASE DESCRIPTION: A 43-year-old man with a history of intravenous drug use, Hepatitis C, and no evidence of immunocompromise presented with worseni...

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Autores principales: Air, Ellen L., Vagal, Achala A., Kendler, Ady, McPherson, Christopher M.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011109/
https://www.ncbi.nlm.nih.gov/pubmed/21206542
http://dx.doi.org/10.4103/2152-7806.73800
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author Air, Ellen L.
Vagal, Achala A.
Kendler, Ady
McPherson, Christopher M.
author_facet Air, Ellen L.
Vagal, Achala A.
Kendler, Ady
McPherson, Christopher M.
author_sort Air, Ellen L.
collection PubMed
description BACKGROUND: Mucormycosis is a rare, aggressive fungal disease with high mortality, typically presenting as rhinosinusitis in immunocompromised patients. CASE DESCRIPTION: A 43-year-old man with a history of intravenous drug use, Hepatitis C, and no evidence of immunocompromise presented with worsening balance problems. He had received intravenous antibiotics 2.5 years earlier for local infection after injecting heroin into a neck vein. Imaging studies revealed a lesion, likely of neoplastic origin. At resection, purulent fluid sampled by neuropathology revealed right-angled, branching hyphae, suggesting mucormycosis. No further resection was performed, no other disease sites were found, and HIV findings were negative. Two weeks postoperatively, he developed renal failure; intravenous antifungal treatment and hemodialysis were discontinued. When kidney function recovered 2 weeks later, he declined additional treatment. CONCLUSION: In our immunocompetent patient, both the location of the infection in the posterior fossa and its slowly progressive characteristic were unique variations of this typically aggressive disease.
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spelling pubmed-30111092011-01-04 Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient Air, Ellen L. Vagal, Achala A. Kendler, Ady McPherson, Christopher M. Surg Neurol Int Case Report BACKGROUND: Mucormycosis is a rare, aggressive fungal disease with high mortality, typically presenting as rhinosinusitis in immunocompromised patients. CASE DESCRIPTION: A 43-year-old man with a history of intravenous drug use, Hepatitis C, and no evidence of immunocompromise presented with worsening balance problems. He had received intravenous antibiotics 2.5 years earlier for local infection after injecting heroin into a neck vein. Imaging studies revealed a lesion, likely of neoplastic origin. At resection, purulent fluid sampled by neuropathology revealed right-angled, branching hyphae, suggesting mucormycosis. No further resection was performed, no other disease sites were found, and HIV findings were negative. Two weeks postoperatively, he developed renal failure; intravenous antifungal treatment and hemodialysis were discontinued. When kidney function recovered 2 weeks later, he declined additional treatment. CONCLUSION: In our immunocompetent patient, both the location of the infection in the posterior fossa and its slowly progressive characteristic were unique variations of this typically aggressive disease. Medknow Publications 2010-12-13 /pmc/articles/PMC3011109/ /pubmed/21206542 http://dx.doi.org/10.4103/2152-7806.73800 Text en © 2010 Air EL http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Air, Ellen L.
Vagal, Achala A.
Kendler, Ady
McPherson, Christopher M.
Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient
title Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient
title_full Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient
title_fullStr Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient
title_full_unstemmed Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient
title_short Isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient
title_sort isolated cerebellar mucormycosis, slowly progressive over 1 year in an immunocompetent patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011109/
https://www.ncbi.nlm.nih.gov/pubmed/21206542
http://dx.doi.org/10.4103/2152-7806.73800
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