Selective activation of p53-mediated tumour suppression in high-grade tumours

Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related death worldwide, with an overall 5-year survival rate of only 10–15% 1. Deregulation of the Ras pathway is a frequent hallmark of NSCLC, often through mutations that directly activate Kras 2. p53 is also frequently inactiva...

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Detalles Bibliográficos
Autores principales: Junttila, Melissa R., Karnezis, Anthony, Garcia, Daniel, Madriles, Francesc, Kortlever, Roderik M., Rostker, Fanya, Brown-Swigart, Lamorna, Pham, David M., Seo, Youngho, Evan, Gerard I., Martins, Carla P.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011233/
https://www.ncbi.nlm.nih.gov/pubmed/21107427
http://dx.doi.org/10.1038/nature09526

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