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Pyothorax-associated lymphoma (PAL): report and review of a rare entity
Pyothorax-associated lymphoma (PAL) is a rare haematological malignancy often associated with artificial pneumothorax due to the treatment of pulmonary tuberculosis. A 76 year old man with chronic tube-drained pyothorax and a history of artificial pneumothorax for pulmonary tuberculosis was admitted...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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German Medical Science
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011363/ https://www.ncbi.nlm.nih.gov/pubmed/21289975 |
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author | Welcker, Katrin Nakashima, Masaki Diemel, Klaus-Dieter Welker, Lutz Galle, Jürgen Merz, Hartmut Branscheid, Detlev |
author_facet | Welcker, Katrin Nakashima, Masaki Diemel, Klaus-Dieter Welker, Lutz Galle, Jürgen Merz, Hartmut Branscheid, Detlev |
author_sort | Welcker, Katrin |
collection | PubMed |
description | Pyothorax-associated lymphoma (PAL) is a rare haematological malignancy often associated with artificial pneumothorax due to the treatment of pulmonary tuberculosis. A 76 year old man with chronic tube-drained pyothorax and a history of artificial pneumothorax for pulmonary tuberculosis was admitted to our hospital because of progressive right thoracic pain, weight loss, and pyrexia. After clinical examination and imaging processes a chest wall tumour anterior on the right side was diagnosed as well as a persisting pyothorax. Surgery was performed to resect the tumour and drain the pleural cavity. A diagnosis of a high grade B-cell lymphoma was established after histological examination of the surgical biopsy. Epstein-Barr virus (EBV) was identified in the tumour by immunocytochemical and molecular methods. Additional gastric involvement of B-cell lymphoma could be diagnosed by gastroscopy because of postoperative gastrointestinal bleeding. The patient received chemotherapy with 2 courses of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP). The response was favourable initially, but 2 months later the patient died because of lymphoma progression. Most cases of PAL have been described by Japanese investigators and only a few cases are reported in Western countries. To the best of our knowledge this case of PAL is the first to be documented in Germany. Awareness of this rare entity, together with diligent histological examination, in patients with chronic pyothorax are essential for a correct diagnosis and correct early treatment. |
format | Text |
id | pubmed-3011363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | German Medical Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30113632011-02-02 Pyothorax-associated lymphoma (PAL): report and review of a rare entity Welcker, Katrin Nakashima, Masaki Diemel, Klaus-Dieter Welker, Lutz Galle, Jürgen Merz, Hartmut Branscheid, Detlev Thorac Surg Sci Article Pyothorax-associated lymphoma (PAL) is a rare haematological malignancy often associated with artificial pneumothorax due to the treatment of pulmonary tuberculosis. A 76 year old man with chronic tube-drained pyothorax and a history of artificial pneumothorax for pulmonary tuberculosis was admitted to our hospital because of progressive right thoracic pain, weight loss, and pyrexia. After clinical examination and imaging processes a chest wall tumour anterior on the right side was diagnosed as well as a persisting pyothorax. Surgery was performed to resect the tumour and drain the pleural cavity. A diagnosis of a high grade B-cell lymphoma was established after histological examination of the surgical biopsy. Epstein-Barr virus (EBV) was identified in the tumour by immunocytochemical and molecular methods. Additional gastric involvement of B-cell lymphoma could be diagnosed by gastroscopy because of postoperative gastrointestinal bleeding. The patient received chemotherapy with 2 courses of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP). The response was favourable initially, but 2 months later the patient died because of lymphoma progression. Most cases of PAL have been described by Japanese investigators and only a few cases are reported in Western countries. To the best of our knowledge this case of PAL is the first to be documented in Germany. Awareness of this rare entity, together with diligent histological examination, in patients with chronic pyothorax are essential for a correct diagnosis and correct early treatment. German Medical Science 2004-10-01 /pmc/articles/PMC3011363/ /pubmed/21289975 Text en Copyright © 2004 Welcker et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Article Welcker, Katrin Nakashima, Masaki Diemel, Klaus-Dieter Welker, Lutz Galle, Jürgen Merz, Hartmut Branscheid, Detlev Pyothorax-associated lymphoma (PAL): report and review of a rare entity |
title | Pyothorax-associated lymphoma (PAL): report and review of a rare entity |
title_full | Pyothorax-associated lymphoma (PAL): report and review of a rare entity |
title_fullStr | Pyothorax-associated lymphoma (PAL): report and review of a rare entity |
title_full_unstemmed | Pyothorax-associated lymphoma (PAL): report and review of a rare entity |
title_short | Pyothorax-associated lymphoma (PAL): report and review of a rare entity |
title_sort | pyothorax-associated lymphoma (pal): report and review of a rare entity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011363/ https://www.ncbi.nlm.nih.gov/pubmed/21289975 |
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