Cargando…

Pyothorax-associated lymphoma (PAL): report and review of a rare entity

Pyothorax-associated lymphoma (PAL) is a rare haematological malignancy often associated with artificial pneumothorax due to the treatment of pulmonary tuberculosis. A 76 year old man with chronic tube-drained pyothorax and a history of artificial pneumothorax for pulmonary tuberculosis was admitted...

Descripción completa

Detalles Bibliográficos
Autores principales: Welcker, Katrin, Nakashima, Masaki, Diemel, Klaus-Dieter, Welker, Lutz, Galle, Jürgen, Merz, Hartmut, Branscheid, Detlev
Formato: Texto
Lenguaje:English
Publicado: German Medical Science 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011363/
https://www.ncbi.nlm.nih.gov/pubmed/21289975
_version_ 1782194923952406528
author Welcker, Katrin
Nakashima, Masaki
Diemel, Klaus-Dieter
Welker, Lutz
Galle, Jürgen
Merz, Hartmut
Branscheid, Detlev
author_facet Welcker, Katrin
Nakashima, Masaki
Diemel, Klaus-Dieter
Welker, Lutz
Galle, Jürgen
Merz, Hartmut
Branscheid, Detlev
author_sort Welcker, Katrin
collection PubMed
description Pyothorax-associated lymphoma (PAL) is a rare haematological malignancy often associated with artificial pneumothorax due to the treatment of pulmonary tuberculosis. A 76 year old man with chronic tube-drained pyothorax and a history of artificial pneumothorax for pulmonary tuberculosis was admitted to our hospital because of progressive right thoracic pain, weight loss, and pyrexia. After clinical examination and imaging processes a chest wall tumour anterior on the right side was diagnosed as well as a persisting pyothorax. Surgery was performed to resect the tumour and drain the pleural cavity. A diagnosis of a high grade B-cell lymphoma was established after histological examination of the surgical biopsy. Epstein-Barr virus (EBV) was identified in the tumour by immunocytochemical and molecular methods. Additional gastric involvement of B-cell lymphoma could be diagnosed by gastroscopy because of postoperative gastrointestinal bleeding. The patient received chemotherapy with 2 courses of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP). The response was favourable initially, but 2 months later the patient died because of lymphoma progression. Most cases of PAL have been described by Japanese investigators and only a few cases are reported in Western countries. To the best of our knowledge this case of PAL is the first to be documented in Germany. Awareness of this rare entity, together with diligent histological examination, in patients with chronic pyothorax are essential for a correct diagnosis and correct early treatment.
format Text
id pubmed-3011363
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher German Medical Science
record_format MEDLINE/PubMed
spelling pubmed-30113632011-02-02 Pyothorax-associated lymphoma (PAL): report and review of a rare entity Welcker, Katrin Nakashima, Masaki Diemel, Klaus-Dieter Welker, Lutz Galle, Jürgen Merz, Hartmut Branscheid, Detlev Thorac Surg Sci Article Pyothorax-associated lymphoma (PAL) is a rare haematological malignancy often associated with artificial pneumothorax due to the treatment of pulmonary tuberculosis. A 76 year old man with chronic tube-drained pyothorax and a history of artificial pneumothorax for pulmonary tuberculosis was admitted to our hospital because of progressive right thoracic pain, weight loss, and pyrexia. After clinical examination and imaging processes a chest wall tumour anterior on the right side was diagnosed as well as a persisting pyothorax. Surgery was performed to resect the tumour and drain the pleural cavity. A diagnosis of a high grade B-cell lymphoma was established after histological examination of the surgical biopsy. Epstein-Barr virus (EBV) was identified in the tumour by immunocytochemical and molecular methods. Additional gastric involvement of B-cell lymphoma could be diagnosed by gastroscopy because of postoperative gastrointestinal bleeding. The patient received chemotherapy with 2 courses of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP). The response was favourable initially, but 2 months later the patient died because of lymphoma progression. Most cases of PAL have been described by Japanese investigators and only a few cases are reported in Western countries. To the best of our knowledge this case of PAL is the first to be documented in Germany. Awareness of this rare entity, together with diligent histological examination, in patients with chronic pyothorax are essential for a correct diagnosis and correct early treatment. German Medical Science 2004-10-01 /pmc/articles/PMC3011363/ /pubmed/21289975 Text en Copyright © 2004 Welcker et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Article
Welcker, Katrin
Nakashima, Masaki
Diemel, Klaus-Dieter
Welker, Lutz
Galle, Jürgen
Merz, Hartmut
Branscheid, Detlev
Pyothorax-associated lymphoma (PAL): report and review of a rare entity
title Pyothorax-associated lymphoma (PAL): report and review of a rare entity
title_full Pyothorax-associated lymphoma (PAL): report and review of a rare entity
title_fullStr Pyothorax-associated lymphoma (PAL): report and review of a rare entity
title_full_unstemmed Pyothorax-associated lymphoma (PAL): report and review of a rare entity
title_short Pyothorax-associated lymphoma (PAL): report and review of a rare entity
title_sort pyothorax-associated lymphoma (pal): report and review of a rare entity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011363/
https://www.ncbi.nlm.nih.gov/pubmed/21289975
work_keys_str_mv AT welckerkatrin pyothoraxassociatedlymphomapalreportandreviewofarareentity
AT nakashimamasaki pyothoraxassociatedlymphomapalreportandreviewofarareentity
AT diemelklausdieter pyothoraxassociatedlymphomapalreportandreviewofarareentity
AT welkerlutz pyothoraxassociatedlymphomapalreportandreviewofarareentity
AT gallejurgen pyothoraxassociatedlymphomapalreportandreviewofarareentity
AT merzhartmut pyothoraxassociatedlymphomapalreportandreviewofarareentity
AT branscheiddetlev pyothoraxassociatedlymphomapalreportandreviewofarareentity