rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide

The title compound, C(26)H(24)FNO(3), is a critical inter­mediate of a selective and competitive inhibitor of the enzyme 3-hy­droxy-3-methyl­glutaryl-coenzyme A (HMG–CoA) reductase. Inter­molecular N—H⋯O hydrogen bonding generates a chain along [give direction] that is the dominant inter­action in t...

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Detalles Bibliográficos
Autores principales: Zhou, Feng-yan, Huang, Jian-ying
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011484/
https://www.ncbi.nlm.nih.gov/pubmed/21589464
http://dx.doi.org/10.1107/S1600536810046271
Descripción
Sumario:The title compound, C(26)H(24)FNO(3), is a critical inter­mediate of a selective and competitive inhibitor of the enzyme 3-hy­droxy-3-methyl­glutaryl-coenzyme A (HMG–CoA) reductase. Inter­molecular N—H⋯O hydrogen bonding generates a chain along [give direction] that is the dominant inter­action in the crystal packing. Inter­molecular C—H⋯O inter­actions are also observed.

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