rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide

The title compound, C(26)H(24)FNO(3), is a critical inter­mediate of a selective and competitive inhibitor of the enzyme 3-hy­droxy-3-methyl­glutaryl-coenzyme A (HMG–CoA) reductase. Inter­molecular N—H⋯O hydrogen bonding generates a chain along [give direction] that is the dominant inter­action in t...

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Detalles Bibliográficos
Autores principales: Zhou, Feng-yan, Huang, Jian-ying
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011484/
https://www.ncbi.nlm.nih.gov/pubmed/21589464
http://dx.doi.org/10.1107/S1600536810046271
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author Zhou, Feng-yan
Huang, Jian-ying
author_facet Zhou, Feng-yan
Huang, Jian-ying
author_sort Zhou, Feng-yan
collection PubMed
description The title compound, C(26)H(24)FNO(3), is a critical inter­mediate of a selective and competitive inhibitor of the enzyme 3-hy­droxy-3-methyl­glutaryl-coenzyme A (HMG–CoA) reductase. Inter­molecular N—H⋯O hydrogen bonding generates a chain along [give direction] that is the dominant inter­action in the crystal packing. Inter­molecular C—H⋯O inter­actions are also observed.
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spelling pubmed-30114842010-12-30 rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide Zhou, Feng-yan Huang, Jian-ying Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(26)H(24)FNO(3), is a critical inter­mediate of a selective and competitive inhibitor of the enzyme 3-hy­droxy-3-methyl­glutaryl-coenzyme A (HMG–CoA) reductase. Inter­molecular N—H⋯O hydrogen bonding generates a chain along [give direction] that is the dominant inter­action in the crystal packing. Inter­molecular C—H⋯O inter­actions are also observed. International Union of Crystallography 2010-11-13 /pmc/articles/PMC3011484/ /pubmed/21589464 http://dx.doi.org/10.1107/S1600536810046271 Text en © Zhou and Huang 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Zhou, Feng-yan
Huang, Jian-ying
rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide
title rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide
title_full rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide
title_fullStr rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide
title_full_unstemmed rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide
title_short rac-2-[2-(4-Fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-N-phenyl­penta­namide
title_sort rac-2-[2-(4-fluoro­phen­yl)-2-oxo-1-phenyl­eth­yl]-4-methyl-3-oxo-n-phenyl­penta­namide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011484/
https://www.ncbi.nlm.nih.gov/pubmed/21589464
http://dx.doi.org/10.1107/S1600536810046271
work_keys_str_mv AT zhoufengyan rac224fluorophenyl2oxo1phenylethyl4methyl3oxonphenylpentanamide
AT huangjianying rac224fluorophenyl2oxo1phenylethyl4methyl3oxonphenylpentanamide

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