The dicyclo­hexyl­amine salt of RG108 (N-phthalyl-l-tryptophan), a potential epigenetic modulator

The dicyclo­hexyl­amine salt of RG108 (N-phthalyl-l-tryptophan) co-crystallizes with a water mol­ecule and a disordered mol­ecule of dimethyl­formamide (DMF), viz. dicyclo­hexyl­aminium (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoate dimethyl­formamide solvate monohydrate, C(12)H(24)N(+...

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Detalles Bibliográficos
Autores principales: Braun, Julie, Boittiaux, Irving, Tilborg, Anaelle, Lambert, Didier, Wouters, Johan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011641/
https://www.ncbi.nlm.nih.gov/pubmed/21589471
http://dx.doi.org/10.1107/S160053681004626X
Descripción
Sumario:The dicyclo­hexyl­amine salt of RG108 (N-phthalyl-l-tryptophan) co-crystallizes with a water mol­ecule and a disordered mol­ecule of dimethyl­formamide (DMF), viz. dicyclo­hexyl­aminium (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoate dimethyl­formamide solvate monohydrate, C(12)H(24)N(+)·C(19)H(13)N(2)O(4) (−)·C(3)H(7)NO·H(2)O. The conformation of the deprotonated compound is constrained by charge-assisted strong hydrogen bonds with the dicyclo­hexyl­aminium ion and a dense hydrogen-bond network involving co-crystallized solvent mol­ecules. The dihedral angle between the fused ring systems in the anion is 58.35 (4)°.

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