Cargando…

NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

Dysfunction of β-cell is one of major characteristics in the pathogenesis of type 2 diabetes. The combination of obesity and type 2 diabetes, characterized as ‘diabesity’, is associated with elevated plasma free fatty acids (FFAs). Oxidative stress has been implicated in the pathogenesis of FFA-indu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Huiping, Zhang, Xiaoyong, Huang, Xiuqing, Lu, Yonggang, Tang, Weiqing, Man, Yong, Wang, Shu, Xi, Jianzhong, Li, Jian
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012098/ https://www.ncbi.nlm.nih.gov/pubmed/21209957 http://dx.doi.org/10.1371/journal.pone.0015726

Ejemplares similares

Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models
por: Tong, Huichun, et al.
Publicado: (2018)

Chlamydia trachomatis Requires Functional Host-Cell Mitochondria and NADPH Oxidase 4/p38MAPK Signaling for Growth in Normoxia
por: Thapa, Jeewan, et al.
Publicado: (2022)

Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma
por: Pua, Lesley Jia Wei, et al.
Publicado: (2022)

Data on the phosphorylation of p38MAPK and JNK induced by chlorpyrifos in Drosophila melanogaster
por: Batista, J.E.S., et al.
Publicado: (2016)

Space charge issues in FFAs
por: Machida, Shinji, et al.
Publicado: (2019)

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK
por: Pereira, Lorena, et al.
Publicado: (2013)

Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells
por: Lee, I-Ta, et al.
Publicado: (2012)

Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways
por: Xu, Xingang, et al.
Publicado: (2019)

Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain
por: Yang, Yang, et al.
Publicado: (2022)

A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation
por: Liu, Xin, et al.
Publicado: (2016)

FFAS server: novel features and applications
por: Jaroszewski, Lukasz, et al.
Publicado: (2011)

The Increase of ROS Caused by the Interference of DEHP with JNK/p38/p53 Pathway as the Reason for Hepatotoxicity
por: Huang, Yuanyuan, et al.
Publicado: (2019)

The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells
por: Zhu, Liqian, et al.
Publicado: (2016)

Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways
por: Yang, Zhangshuo, et al.
Publicado: (2022)

Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways
por: Hernandez, Isabelle, et al.
Publicado: (2021)

Actin Cytoskeleton Regulation by the Yeast NADPH Oxidase Yno1p Impacts Processes Controlled by MAPK Pathways
por: Weber, Manuela, et al.
Publicado: (2021)

Ligustilide attenuates nitric oxide‐induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways
por: Zhou, Yan, et al.
Publicado: (2019)

Participation of lipopolysaccharide in hyperplasic adipose expansion: Involvement of NADPH oxidase/ROS/p42/p44 MAPK‐dependent Cyclooxygenase‐2
por: Chang, Chao‐Chien, et al.
Publicado: (2022)

RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38
por: Weilbacher, A, et al.
Publicado: (2014)

Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally
por: Du, Jin, et al.
Publicado: (2019)

Nonthermal Plasma Induces Apoptosis in ATC Cells: Involvement of JNK and p38 MAPK-Dependent ROS
por: Lee, Sei Young, et al.
Publicado: (2014)

Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways
por: Wang, Shan, et al.
Publicado: (2018)

Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway
por: Yang, Xiaorong, et al.
Publicado: (2018)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

LZAP Inhibits p38 MAPK (p38) Phosphorylation and Activity by Facilitating p38 Association with the Wild-Type p53 Induced Phosphatase 1 (WIP1)
por: An, Hanbing, et al.
Publicado: (2011)

Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
por: Perfettini, Jean-Luc, et al.
Publicado: (2005)

JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells
por: Yan, Ling, et al.
Publicado: (2013)

Dexamethasone Induces Apoptosis of Nasal Polyp-Derived Tissue Cultures Through JNK and p38 MAPK Activation
por: Lee, Tae-Hoon, et al.
Publicado: (2014)

Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways
por: Liu, Haojie, et al.
Publicado: (2017)

High glucose promotes annulus fibrosus cell apoptosis through activating the JNK and p38 MAPK pathways
por: Shan, Lizhen, et al.
Publicado: (2019)

A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing
por: Lanna, Alessio, et al.
Publicado: (2017)

Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression
por: Chen, Xueran, et al.
Publicado: (2020)

Butorphanol reduces the neuronal inflammatory response and apoptosis via inhibition of p38/JNK/ATF2/p53 signaling
por: Huang, Yingsi, et al.
Publicado: (2022)

Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells
por: Taylor, Catherine A, et al.
Publicado: (2013)

NADPH Oxidase and Neurodegeneration
por: Hernandes, Marina S, et al.
Publicado: (2012)

Coronarin D induces reactive oxygen species-mediated cell death in human nasopharyngeal cancer cells through inhibition of p38 MAPK and activation of JNK
por: Chen, Jui-Chieh, et al.
Publicado: (2017)

New Insights into the p38γ and p38δ MAPK Pathways
por: Risco, Ana, et al.
Publicado: (2012)

A p38mapk-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells
por: Hadjal, Y, et al.
Publicado: (2013)

Polyamine Oxidase-Generated Reactive Oxygen Species in Plant Development and Adaptation: The Polyamine Oxidase—NADPH Oxidase Nexus
por: Benkő, Péter, et al.
Publicado: (2022)

Contribution of NADPH Oxidase to Membrane CD38 Internalization and Activation in Coronary Arterial Myocytes
por: Xu, Ming, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tt0noa85csurim8arl2bs0fclt