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1, 9-Pyrazoloanthrones Downregulate HIF-1α and Sensitize Cancer Cells to Cetuximab-Mediated Anti-EGFR Therapy

Cetuximab, a monoclonal antibody that blocks the epidermal growth factor receptor (EGFR), is currently approved for the treatment of several types of solid tumors. We previously showed that cetuximab can inhibit hypoxia-inducible factor-1 alpha (HIF-1α) protein synthesis by inhibiting the activation...

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Detalles Bibliográficos
Autores principales:	Lu, Yang, Li, Xinqun, Lu, Haiquan, Fan, Zhen
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012113/ https://www.ncbi.nlm.nih.gov/pubmed/21209911 http://dx.doi.org/10.1371/journal.pone.0015823

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