Cargando…

Endothelium-Based Biomarkers Are Associated with Cerebral Malaria in Malawian Children: A Retrospective Case-Control Study

BACKGROUND: Differentiating cerebral malaria (CM) from other causes of serious illness in African children is problematic, owing to the non-specific nature of the clinical presentation and the high prevalence of incidental parasitaemia. CM is associated with endothelial activation. In this study we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conroy, Andrea L., Phiri, Happy, Hawkes, Michael, Glover, Simon, Mallewa, Mac, Seydel, Karl B., Taylor, Terrie E., Molyneux, Malcolm E., Kain, Kevin C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012131/ https://www.ncbi.nlm.nih.gov/pubmed/21209923 http://dx.doi.org/10.1371/journal.pone.0015291

Ejemplares similares

HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children
por: Mbale, Emmie W., et al.
Publicado: (2016)

Elevated Plasma Von Willebrand Factor and Propeptide Levels in Malawian Children with Malaria
por: Phiri, Happy T., et al.
Publicado: (2011)

The Neuropathology of Fatal Cerebral Malaria in Malawian Children
por: Dorovini-Zis, Katerina, et al.
Publicado: (2011)

Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian Children
por: Feintuch, Catherine Manix, et al.
Publicado: (2016)

Brain swelling is independent of peripheral plasma cytokine levels in Malawian children with cerebral malaria
por: Harawa, Visopo, et al.
Publicado: (2018)

HIV infection compounds the lymphopenia associated with cerebral malaria in Malawian children
por: Mandala, Wilson L, et al.
Publicado: (2018)

Lymphocyte Perturbations in Malawian Children with Severe and Uncomplicated Malaria
por: Mandala, Wilson L., et al.
Publicado: (2016)

Correlation of hemorrhage, axonal damage, and blood-tissue barrier disruption in brain and retina of Malawian children with fatal cerebral malaria
por: Greiner, Jesse, et al.
Publicado: (2015)

Cytokine Profiles in Malawian Children Presenting with Uncomplicated Malaria, Severe Malarial Anemia, and Cerebral Malaria
por: Mandala, Wilson L., et al.
Publicado: (2017)

The systemic pathology of cerebral malaria in African children
por: Milner, Danny A., et al.
Publicado: (2014)

Severity of Retinopathy Parallels the Degree of Parasite Sequestration in the Eyes and Brains of Malawian Children With Fatal Cerebral Malaria
por: Barrera, Valentina, et al.
Publicado: (2015)

“We can’t handle things we don’t know about”: perceived neurorehabilitation challenges for Malawian paediatric cerebral malaria survivors
por: Boubour, Alexandra, et al.
Publicado: (2020)

Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study
por: Birbeck, Gretchen L, et al.
Publicado: (2010)

Persistent Endothelial Activation and Inflammation After Plasmodium falciparum Infection in Malawian Children
por: Moxon, Christopher A., et al.
Publicado: (2014)

Plasmodium falciparum clearance time in Malawian children with cerebral malaria: a retrospective cohort study
por: Saidi, Alexuse M., et al.
Publicado: (2021)

The Platelet Count in Cerebral Malaria, Is It Useful to the Clinician?
por: Chimalizeni, Yamikani, et al.
Publicado: (2010)

How Does Blood-Retinal Barrier Breakdown Relate to Death and Disability in Pediatric Cerebral Malaria?
por: MacCormick, Ian J C, et al.
Publicado: (2020)

The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
por: Mankhambo, Limangeni A, et al.
Publicado: (2010)

Evoked potentials in pediatric cerebral malaria
por: Bhanushali, Minal, et al.
Publicado: (2011)

Retinal Pathology of Pediatric Cerebral Malaria in Malawi
por: White, Valerie A., et al.
Publicado: (2009)

Safety of lumbar puncture in comatose children with clinical features of cerebral malaria
por: Moxon, Christopher A., et al.
Publicado: (2016)

Automated Detection of Malarial Retinopathy in Digital Fundus Images for Improved Diagnosis in Malawian Children with Clinically Defined Cerebral Malaria
por: Joshi, Vinayak, et al.
Publicado: (2017)

A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria
por: Milner, Danny A, et al.
Publicado: (2013)

Evidence from a natural experiment that malaria parasitemia is pathogenic in retinopathy-negative cerebral malaria
por: Small, Dylan S, et al.
Publicado: (2017)

Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children
por: Wilson, Kyle J, et al.
Publicado: (2023)

Acute Malaria in Malawian Children and Adults is Characterized by Thrombocytopenia That Normalizes in Convalescence
por: Mandala, Wilson, et al.
Publicado: (2022)

Long Term Outcome of Severe Anaemia in Malawian Children
por: Phiri, Kamija S., et al.
Publicado: (2008)

A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria
por: Birbeck, Gretchen L., et al.
Publicado: (2019)

Noninvasive measures of brain edema predict outcome in pediatric cerebral malaria
por: Kampondeni, Samuel D., et al.
Publicado: (2018)

Monocyte activation and cytokine production in Malawian children presenting with P. falciparum malaria
por: Mandala, W. L., et al.
Publicado: (2016)

Pathophysiological Mechanisms of Severe Anaemia in Malawian Children
por: Boele van Hensbroek, Michaël, et al.
Publicado: (2010)

Neurocognitive outcomes in Malawian children exposed to malaria during pregnancy: An observational birth cohort study
por: Weckman, Andrea M., et al.
Publicado: (2021)

Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children
por: Irwin, Adam D, et al.
Publicado: (2012)

Contrasting pediatric and adult cerebral malaria: The role of the endothelial barrier
por: Hawkes, Michael, et al.
Publicado: (2013)

Age- and sex-related changes in hematological parameters in healthy Malawians
por: Mandala, Wilson L, et al.
Publicado: (2017)

Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection
por: Hochman, Sarah E., et al.
Publicado: (2015)

T-Regulatory Cells and Inflammatory and Inhibitory Cytokines in Malawian Children Residing in an Area of High and an Area of Low Malaria Transmission During Acute Uncomplicated Malaria and in Convalescence
por: Nyirenda, Tonney S., et al.
Publicado: (2015)

Cerebral malaria in children: using the retina to study the brain
por: MacCormick, Ian J. C., et al.
Publicado: (2014)

Decreasing Burden of Malaria in Pregnancy in Malawian Women and Its Relationship to Use of Intermittent Preventive Therapy or Bed Nets
por: Feng, Gaoqian, et al.
Publicado: (2010)

Malarial retinopathy affecting visual function in a Malawian adult with cerebral malaria
por: Piddock, Katherine, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_2mds5qnt8bkbrpges3rr5facp1