The Fanconi Anemia Core Complex Is Dispensable during Somatic Hypermutation and Class Switch Recombination

To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone translesion synthesis (TLS) DNA polymerases have been reported to be responsible for all mutations at template A/T and at least a fraction of G/C tra...

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Detalles Bibliográficos
Autores principales: Krijger, Peter H. L., Wit, Niek, van den Berk, Paul C. M., Jacobs, Heinz
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012132/
https://www.ncbi.nlm.nih.gov/pubmed/21209924
http://dx.doi.org/10.1371/journal.pone.0015236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012132/
https://www.ncbi.nlm.nih.gov/pubmed/21209924
http://dx.doi.org/10.1371/journal.pone.0015236

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