Cargando…

The Fanconi Anemia Core Complex Is Dispensable during Somatic Hypermutation and Class Switch Recombination

To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone translesion synthesis (TLS) DNA polymerases have been reported to be responsible for all mutations at template A/T and at least a fraction of G/C tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krijger, Peter H. L., Wit, Niek, van den Berk, Paul C. M., Jacobs, Heinz
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012132/ https://www.ncbi.nlm.nih.gov/pubmed/21209924 http://dx.doi.org/10.1371/journal.pone.0015236

Ejemplares similares

AID function in somatic hypermutation and class switch recombination: AID function in somatic hypermutation and class switch recombination
por: Yu, Kefei
Publicado: (2022)

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation
por: Krijger, Peter H.L., et al.
Publicado: (2009)

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation
por: Spanjaard, Aldo, et al.
Publicado: (2023)

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
por: Pan-Hammarström, Qiang, et al.
Publicado: (2006)

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
por: Martomo, Stella A., et al.
Publicado: (2004)

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen(K164R) mutant mice
por: Langerak, Petra, et al.
Publicado: (2008)

Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
por: Martin, Alberto, et al.
Publicado: (2003)

Tandem Substitutions in Somatic Hypermutation
por: Sepúlveda-Yáñez, Julieta H., et al.
Publicado: (2022)

Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region
por: Dunnick, Wesley A., et al.
Publicado: (2009)

Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation
por: Nagaoka, Hitoshi, et al.
Publicado: (2002)

HoxC4 binds to the Aicda promoter to induce AID expression, class switch DNA recombination and somatic hypermutation
por: Park, Seok-Rae, et al.
Publicado: (2009)

Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
por: Nguyen, Thuy Vy, et al.
Publicado: (2014)

SNV/indel hypermutator phenotype in biallelic RAD51C variant - Fanconi anemia
por: Zemet, Roni, et al.
Publicado: (2023)

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
por: Reina-San-Martin, Bernardo, et al.
Publicado: (2003)

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNA(K164) modification
por: Langerak, Petra, et al.
Publicado: (2007)

Mutating for Good: DNA Damage Responses During Somatic Hypermutation
por: Pilzecker, Bas, et al.
Publicado: (2019)

DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination
por: Faili, Ahmad, et al.
Publicado: (2004)

Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation
por: Maizels, Nancy
Publicado: (2000)

Lysine Residue 185 of Rad1 Is a Topological but Not a Functional Counterpart of Lysine Residue 164 of PCNA
por: Wit, Niek, et al.
Publicado: (2011)

Regulation of Rev1 by the Fanconi Anemia Core Complex
por: Kim, Hyungjin, et al.
Publicado: (2012)

Mutated Fanconi anemia pathway in non-Fanconi anemia cancers
por: Shen, Yihang, et al.
Publicado: (2015)

Towards a Molecular Understanding of the Fanconi Anemia Core Complex
por: Hodson, Charlotte, et al.
Publicado: (2012)

The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex
por: Cole, Ambrose R., et al.
Publicado: (2010)

Regulation of class switch recombination and somatic mutation by AID phosphorylation
por: McBride, Kevin M., et al.
Publicado: (2008)

Attracting AID to targets of somatic hypermutation
por: Tanaka, Atsushi, et al.
Publicado: (2010)

Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia
por: Petrova, Velislava N., et al.
Publicado: (2018)

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity
por: Michl, Johanna, et al.
Publicado: (2016)

Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis
por: Nguyen, Hang Thi Thu, et al.
Publicado: (2021)

Identifying protein–protein interactions in somatic hypermutation
por: Goodman, Myron F., et al.
Publicado: (2005)

Recurrent targets of aberrant somatic hypermutation in lymphoma
por: Khodabakhshi, Alireza Hadj, et al.
Publicado: (2012)

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors
por: Landais, Igor, et al.
Publicado: (2009)

The Fanconi anemia pathway and ubiquitin
por: Jacquemont, Céline, et al.
Publicado: (2007)

Disparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesis
por: Hinz, John M., et al.
Publicado: (2007)

One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation
por: Jacobsen, Johanne T., et al.
Publicado: (2018)

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
por: Jansen, Jacob G., et al.
Publicado: (2006)

ALKBH1 Is Dispensable for Abasic Site Cleavage during Base Excision Repair and Class Switch Recombination
por: Müller, Tina A., et al.
Publicado: (2013)

Somatic hypermutation of an immunoglobulin mu heavy chain transgene
Publicado: (1993)

The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes
por: Kim, Nayun, et al.
Publicado: (1998)

UNG shapes the specificity of AID-induced somatic hypermutation
por: Pérez-Durán, Pablo, et al.
Publicado: (2012)

Checkpoint kinase 1 negatively regulates somatic hypermutation
por: Frankenberger, Samantha, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6pa4kgaiem3923dv8u9tuctfvq