Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress

Prion-related disorders (PrDs) are fatal neurodegenerative disorders characterized by progressive neuronal impairment as well as the accumulation of an abnormally folded and protease resistant form of the cellular prion protein, termed PrP(RES). Altered endoplasmic reticulum (ER) homeostasis is asso...

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Detalles Bibliográficos
Autores principales: Torres, Mauricio, Castillo, Karen, Armisén, Ricardo, Stutzin, Andrés, Soto, Claudio, Hetz, Claudio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012133/
https://www.ncbi.nlm.nih.gov/pubmed/21209925
http://dx.doi.org/10.1371/journal.pone.0015658

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