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Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase

OBJECTIVE: We investigated the function of the Prep1 gene in insulin-dependent glucose homeostasis in liver. RESEARCH DESIGN AND METHODS: Prep1 action on insulin glucoregulatory function has been analyzed in liver of Prep1-hypomorphic mice (Prep1(i/i)), which express 2–3% of Prep1 mRNA. RESULTS: Bas...

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Detalles Bibliográficos
Autores principales:	Oriente, Francesco, Iovino, Salvatore, Cabaro, Serena, Cassese, Angela, Longobardi, Elena, Miele, Claudia, Ungaro, Paola, Formisano, Pietro, Blasi, Francesco, Beguinot, Francesco
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012165/ https://www.ncbi.nlm.nih.gov/pubmed/20864515 http://dx.doi.org/10.2337/db10-0860

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