Cargando…

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

OBJECTIVE: Type 2 diabetes is a complex disease that is accompanied by elevated levels of nonesterified fatty acids (NEFAs), which contribute to β-cell dysfunction and β-cell loss, referred to as lipotoxicity. Experimental evidence suggests that oxidative stress is involved in lipotoxicity. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elsner, Matthias, Gehrmann, Wiebke, Lenzen, Sigurd
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012172/ https://www.ncbi.nlm.nih.gov/pubmed/20971967 http://dx.doi.org/10.2337/db09-1401

Ejemplares similares

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion
por: Cohen, Guy, et al.
Publicado: (2011)

Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes
por: Tong, Xin, et al.
Publicado: (2021)

The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells
por: Plötz, Thomas, et al.
Publicado: (2016)

Neprilysin Is Required for Angiotensin-(1–7)’s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1–2)
por: Brar, Gurkirat S., et al.
Publicado: (2017)

Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell
por: Ohta, Yasuharu, et al.
Publicado: (2011)

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
por: Mezza, Teresa, et al.
Publicado: (2014)

Perilipin 5 Regulates Islet Lipid Metabolism and Insulin Secretion in a cAMP-Dependent Manner: Implication of Its Role in the Postprandial Insulin Secretion
por: Trevino, Michelle B., et al.
Publicado: (2015)

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells
por: Kim, Wook, et al.
Publicado: (2011)

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet
por: Molina, Judith, et al.
Publicado: (2014)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2014)

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes
por: Rosengren, Anders H., et al.
Publicado: (2012)

PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control
por: Kaihara, Kelly A., et al.
Publicado: (2015)

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells
por: Hisanaga, Etsuko, et al.
Publicado: (2009)

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion
por: Leloup, Corinne, et al.
Publicado: (2009)

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
por: Dai, Xiao-Qing, et al.
Publicado: (2011)

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function
por: Olerud, Johan, et al.
Publicado: (2011)

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells
por: Dolai, Subhankar, et al.
Publicado: (2016)

Changes in granule mobility and age contribute to changes in insulin secretion after desensitization or rest
por: Gaus, Bastian, et al.
Publicado: (2021)

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
por: Kruit, Janine K., et al.
Publicado: (2011)

Gαo Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic β-Cells
por: Zhao, Aizhen, et al.
Publicado: (2010)

YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells
por: Liu, Di, et al.
Publicado: (2022)

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca(2+)-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells
por: Demozay, Damien, et al.
Publicado: (2011)

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets
por: Kato, Toyonori, et al.
Publicado: (2008)

Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1–Stimulated Postprandial Insulin Secretion in Humans
por: Salehi, Marzieh, et al.
Publicado: (2011)

Pancreatic β-Cell–Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion
por: Burns, Christian H., et al.
Publicado: (2021)

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice
por: Jouvet, Nathalie, et al.
Publicado: (2021)

Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance
por: Åkerfeldt, Mia C., et al.
Publicado: (2011)

Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass
por: Nguidjoe, Evrard, et al.
Publicado: (2011)

Wld(S) Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis
por: Wu, Jingxia, et al.
Publicado: (2011)

miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets
por: Wijesekara, Nadeeja, et al.
Publicado: (2012)

Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion
por: Hamming, Kevin S.C., et al.
Publicado: (2010)

Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study
por: Keenan, Hillary A., et al.
Publicado: (2010)

Downregulation of Carnitine Acyl-Carnitine Translocase by miRNAs 132 and 212 Amplifies Glucose-Stimulated Insulin Secretion
por: Soni, Mufaddal S., et al.
Publicado: (2014)

Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass
por: Alejandro, Emilyn U., et al.
Publicado: (2017)

Spontaneous Diabetes in Hemizygous Human Amylin Transgenic Mice That Developed Neither Islet Amyloid nor Peripheral Insulin Resistance
por: Wong, Winifred P.S., et al.
Publicado: (2008)

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding
por: Kebede, Melkam, et al.
Publicado: (2008)

Inhibition of Glucose-Stimulated Insulin Secretion by KCNJ15, a Newly Identified Susceptibility Gene for Type 2 Diabetes
por: Okamoto, Koji, et al.
Publicado: (2012)

Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves β-Cell Function Under Stress
por: Gurevitch, Diana, et al.
Publicado: (2010)

Nuclear Hormone Retinoid X Receptor (RXR) Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic β-Cells
por: Miyazaki, Satsuki, et al.
Publicado: (2010)

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion
por: Golson, Maria L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_b5sqkmv8mfshfah7n2rsvvu495