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Targeted Inactivation of Kinesin-1 in Pancreatic β-Cells In Vivo Leads to Insulin Secretory Deficiency

OBJECTIVE: Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role...

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Detalles Bibliográficos
Autores principales:	Cui, Ju, Wang, Zai, Cheng, Qianni, Lin, Raozhou, Zhang, Xin-Mei, Leung, Po Sing, Copeland, Neal G., Jenkins, Nancy A., Yao, Kwok-Ming, Huang, Jian-Dong
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012189/ https://www.ncbi.nlm.nih.gov/pubmed/20870970 http://dx.doi.org/10.2337/db09-1078

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