Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis

OBJECTIVE: Excess tissue iron levels are a risk factor for diabetes, but the mechanisms underlying the association are incompletely understood. We previously published that mice and humans with a form of hereditary iron overload, hemochromatosis, exhibit loss of β-cell mass. This effect by itself is...

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Detalles Bibliográficos
Autores principales: Huang, Jingyu, Jones, Deborah, Luo, Bai, Sanderson, Michael, Soto, Jamie, Abel, E. Dale, Cooksey, Robert C., McClain, Donald A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012200/
https://www.ncbi.nlm.nih.gov/pubmed/20876715
http://dx.doi.org/10.2337/db10-0593

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