EFFECT OF LITHIUM CARBONATE ON RENAL AND EXTRA-RENAL FUNCTIONS OF RATS

Effect of high doses of lithium carbonate (40 rag/Kg.i.p. and p.o.) and lithium chloride (40 mg/Kg.i.p.) on renal and extra-renal functions were studied in normal male Charles Foster Strain of rats. Insignificant effect on urine output, creatinine clerance, sodium, potassium and lithium excretion wa...

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Detalles Bibliográficos
Autor principal: Puri, V.N.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1984
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012255/
https://www.ncbi.nlm.nih.gov/pubmed/21965958
Descripción
Sumario:Effect of high doses of lithium carbonate (40 rag/Kg.i.p. and p.o.) and lithium chloride (40 mg/Kg.i.p.) on renal and extra-renal functions were studied in normal male Charles Foster Strain of rats. Insignificant effect on urine output, creatinine clerance, sodium, potassium and lithium excretion was observed with these salts. Antidiuretic hormone levels were also not effected. However lithium clearance was significantly raised in both groups with lithium carbonate and with lithium chloride treated rats. Lithium carbonate and lithium chloride had failed to produce nephrogenic polyuric syndrome in this strain of rats.

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