Enhancement of Vaccinia Virus Based Oncolysis with Histone Deacetylase Inhibitors

Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation,...

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Detalles Bibliográficos
Autores principales: MacTavish, Heather, Diallo, Jean-Simon, Huang, Baocheng, Stanford, Marianne, Le Boeuf, Fabrice, De Silva, Naomi, Cox, Julie, Simmons, John Graydon, Guimond, Tanya, Falls, Theresa, McCart, J. Andrea, Atkins, Harry, Breitbach, Caroline, Kirn, David, Thorne, Stephen, Bell, John C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012680/
https://www.ncbi.nlm.nih.gov/pubmed/21283510
http://dx.doi.org/10.1371/journal.pone.0014462

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