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Impact of Parenchymal Tuberculosis Sequelae on Mediastinal Lymph Node Staging in Patients with Lung Cancer

Because tuberculous (TB) involvement of mediastinal lymph nodes (LN) could cause false positive results in nodal staging of lung cancer, we examined the accuracy of nodal staging in lung cancer patients with radiographic sequelae of healed TB. A total of 54 lung cancer patients with radiographic TB...

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Autores principales: Lee, Seung Heon, Min, Joo-Won, Lee, Chang Hoon, Park, Chang Min, Goo, Jin Mo, Chung, Doo Hyun, Kang, Chang Hyun, Kim, Young Tae, Kim, Young Whan, Han, Sung Koo, Shim, Young-Soo, Yim, Jae-Joon
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012852/
https://www.ncbi.nlm.nih.gov/pubmed/21218032
http://dx.doi.org/10.3346/jkms.2011.26.1.67
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author Lee, Seung Heon
Min, Joo-Won
Lee, Chang Hoon
Park, Chang Min
Goo, Jin Mo
Chung, Doo Hyun
Kang, Chang Hyun
Kim, Young Tae
Kim, Young Whan
Han, Sung Koo
Shim, Young-Soo
Yim, Jae-Joon
author_facet Lee, Seung Heon
Min, Joo-Won
Lee, Chang Hoon
Park, Chang Min
Goo, Jin Mo
Chung, Doo Hyun
Kang, Chang Hyun
Kim, Young Tae
Kim, Young Whan
Han, Sung Koo
Shim, Young-Soo
Yim, Jae-Joon
author_sort Lee, Seung Heon
collection PubMed
description Because tuberculous (TB) involvement of mediastinal lymph nodes (LN) could cause false positive results in nodal staging of lung cancer, we examined the accuracy of nodal staging in lung cancer patients with radiographic sequelae of healed TB. A total of 54 lung cancer patients with radiographic TB sequelae in the lung parenchyma ipsilateral to the resected lung, who had undergone at least ipsilateral 4- and 7-lymph node dissection after both chest computed tomography (CT) and fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT were included for the analysis. The median age of 54 subjects was 66 yr and 48 were males. Calcified nodules and fibrotic changes were the most common forms of healed parenchymal pulmonary TB. Enlarged mediastinal lymph nodes (short diameter > 1 cm) were identified in 21 patients and positive mediastinal lymph nodes were identified using FDG-PET/CT in 19 patients. The overall sensitivity and specificity for mediastinal node metastasis were 60.0% and 69.2% with CT and 46.7% and 69.2% with FDG-PET/CT, respectively. In conclusion, the accuracy of nodal staging using CT or FDG-PET/CT might be low in lung cancer patients with parenchymal TB sequelae, because of inactive TB lymph nodes without viable TB bacilli.
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spelling pubmed-30128522011-01-08 Impact of Parenchymal Tuberculosis Sequelae on Mediastinal Lymph Node Staging in Patients with Lung Cancer Lee, Seung Heon Min, Joo-Won Lee, Chang Hoon Park, Chang Min Goo, Jin Mo Chung, Doo Hyun Kang, Chang Hyun Kim, Young Tae Kim, Young Whan Han, Sung Koo Shim, Young-Soo Yim, Jae-Joon J Korean Med Sci Original Article Because tuberculous (TB) involvement of mediastinal lymph nodes (LN) could cause false positive results in nodal staging of lung cancer, we examined the accuracy of nodal staging in lung cancer patients with radiographic sequelae of healed TB. A total of 54 lung cancer patients with radiographic TB sequelae in the lung parenchyma ipsilateral to the resected lung, who had undergone at least ipsilateral 4- and 7-lymph node dissection after both chest computed tomography (CT) and fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT were included for the analysis. The median age of 54 subjects was 66 yr and 48 were males. Calcified nodules and fibrotic changes were the most common forms of healed parenchymal pulmonary TB. Enlarged mediastinal lymph nodes (short diameter > 1 cm) were identified in 21 patients and positive mediastinal lymph nodes were identified using FDG-PET/CT in 19 patients. The overall sensitivity and specificity for mediastinal node metastasis were 60.0% and 69.2% with CT and 46.7% and 69.2% with FDG-PET/CT, respectively. In conclusion, the accuracy of nodal staging using CT or FDG-PET/CT might be low in lung cancer patients with parenchymal TB sequelae, because of inactive TB lymph nodes without viable TB bacilli. The Korean Academy of Medical Sciences 2011-01 2010-12-22 /pmc/articles/PMC3012852/ /pubmed/21218032 http://dx.doi.org/10.3346/jkms.2011.26.1.67 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Seung Heon
Min, Joo-Won
Lee, Chang Hoon
Park, Chang Min
Goo, Jin Mo
Chung, Doo Hyun
Kang, Chang Hyun
Kim, Young Tae
Kim, Young Whan
Han, Sung Koo
Shim, Young-Soo
Yim, Jae-Joon
Impact of Parenchymal Tuberculosis Sequelae on Mediastinal Lymph Node Staging in Patients with Lung Cancer
title Impact of Parenchymal Tuberculosis Sequelae on Mediastinal Lymph Node Staging in Patients with Lung Cancer
title_full Impact of Parenchymal Tuberculosis Sequelae on Mediastinal Lymph Node Staging in Patients with Lung Cancer
title_fullStr Impact of Parenchymal Tuberculosis Sequelae on Mediastinal Lymph Node Staging in Patients with Lung Cancer
title_full_unstemmed Impact of Parenchymal Tuberculosis Sequelae on Mediastinal Lymph Node Staging in Patients with Lung Cancer
title_short Impact of Parenchymal Tuberculosis Sequelae on Mediastinal Lymph Node Staging in Patients with Lung Cancer
title_sort impact of parenchymal tuberculosis sequelae on mediastinal lymph node staging in patients with lung cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012852/
https://www.ncbi.nlm.nih.gov/pubmed/21218032
http://dx.doi.org/10.3346/jkms.2011.26.1.67
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