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LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDER

Out of 108 patients on the rolls in the Lithium clinic, Madurai Medical College and Govt. Rajaji Hospital, Madurai, India, 47 patients suffering from affective disorders receiving lithium continuously for more than three years were analysed with a view to study the recurrences. Thirteen suffered no...

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Autores principales: Rao, A. Venkoba, Hariharasubramanian, N., Devi, S. Parvathi, Sugumar, A., Srinivasan, V.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1982
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012877/
https://www.ncbi.nlm.nih.gov/pubmed/21965880
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author Rao, A. Venkoba
Hariharasubramanian, N.
Devi, S. Parvathi
Sugumar, A.
Srinivasan, V.
author_facet Rao, A. Venkoba
Hariharasubramanian, N.
Devi, S. Parvathi
Sugumar, A.
Srinivasan, V.
author_sort Rao, A. Venkoba
collection PubMed
description Out of 108 patients on the rolls in the Lithium clinic, Madurai Medical College and Govt. Rajaji Hospital, Madurai, India, 47 patients suffering from affective disorders receiving lithium continuously for more than three years were analysed with a view to study the recurrences. Thirteen suffered no relapses while on lithium while nineteen experienced them while on lithium. Four were free from recurrences after lithium was withdrawn- Seven defaulted but suffered recurrences while in four the drug was withdrawn and in both the groups remission was achieved with re-administration of lithium. The study reveals that lithium besides averting the recurrences can reduce the frequency, number, duration, intensity of episodes and improve the amenability to drugs. Among the symptoms, suicidal ideas and behaviour and insight were found to be influenced favourably by lithium. Among the factors that help favourable response to lithium were a positive family history of affective disorder, in the first degree relatives and lesser frequency and number of episodes in the pre-lithium period. A reappraisal of the natural history of the illness is called for in the light of lithium prophylaxis of manic depressive psychosis.
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spelling pubmed-30128772011-10-02 LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDER Rao, A. Venkoba Hariharasubramanian, N. Devi, S. Parvathi Sugumar, A. Srinivasan, V. Indian J Psychiatry Original Article Out of 108 patients on the rolls in the Lithium clinic, Madurai Medical College and Govt. Rajaji Hospital, Madurai, India, 47 patients suffering from affective disorders receiving lithium continuously for more than three years were analysed with a view to study the recurrences. Thirteen suffered no relapses while on lithium while nineteen experienced them while on lithium. Four were free from recurrences after lithium was withdrawn- Seven defaulted but suffered recurrences while in four the drug was withdrawn and in both the groups remission was achieved with re-administration of lithium. The study reveals that lithium besides averting the recurrences can reduce the frequency, number, duration, intensity of episodes and improve the amenability to drugs. Among the symptoms, suicidal ideas and behaviour and insight were found to be influenced favourably by lithium. Among the factors that help favourable response to lithium were a positive family history of affective disorder, in the first degree relatives and lesser frequency and number of episodes in the pre-lithium period. A reappraisal of the natural history of the illness is called for in the light of lithium prophylaxis of manic depressive psychosis. Medknow Publications 1982 /pmc/articles/PMC3012877/ /pubmed/21965880 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rao, A. Venkoba
Hariharasubramanian, N.
Devi, S. Parvathi
Sugumar, A.
Srinivasan, V.
LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDER
title LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDER
title_full LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDER
title_fullStr LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDER
title_full_unstemmed LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDER
title_short LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDER
title_sort lithium prophylaxis in affective disorder
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012877/
https://www.ncbi.nlm.nih.gov/pubmed/21965880
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AT srinivasanv lithiumprophylaxisinaffectivedisorder