A BI-COMPARTMENTL MODEL SYSTEM FOR LITHIUM KINETICS IN MANIA

Lithium T½ has been determined from Lp decay. It is clear that calculation of a single T½ from Lp decay is essentially incorrect as the decay is not exponential. The same data points have been analysed on a kinetic model yielding 3 different half lives too. The implication of the study is that the p...

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Detalles Bibliográficos
Autores principales: Pradhan, N., Devi, K. Uma, Channabasavanna, S.M., Subhash, M., Rama Rao, B. S. Sridhara
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1982
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012879/
https://www.ncbi.nlm.nih.gov/pubmed/21965881
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author Pradhan, N.
Devi, K. Uma
Channabasavanna, S.M.
Subhash, M.
Rama Rao, B. S. Sridhara
author_facet Pradhan, N.
Devi, K. Uma
Channabasavanna, S.M.
Subhash, M.
Rama Rao, B. S. Sridhara
author_sort Pradhan, N.
collection PubMed
description Lithium T½ has been determined from Lp decay. It is clear that calculation of a single T½ from Lp decay is essentially incorrect as the decay is not exponential. The same data points have been analysed on a kinetic model yielding 3 different half lives too. The implication of the study is that the plasma and the erythrocyte systems undergo many local steady states instead of any global steady state. The rate of movement of Li (+) across plasma and erythrocyte undergoes fluctuations and may exhibit many more different half lives over a time period in either direction.
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spelling pubmed-30128792011-10-02 A BI-COMPARTMENTL MODEL SYSTEM FOR LITHIUM KINETICS IN MANIA Pradhan, N. Devi, K. Uma Channabasavanna, S.M. Subhash, M. Rama Rao, B. S. Sridhara Indian J Psychiatry Original Article Lithium T½ has been determined from Lp decay. It is clear that calculation of a single T½ from Lp decay is essentially incorrect as the decay is not exponential. The same data points have been analysed on a kinetic model yielding 3 different half lives too. The implication of the study is that the plasma and the erythrocyte systems undergo many local steady states instead of any global steady state. The rate of movement of Li (+) across plasma and erythrocyte undergoes fluctuations and may exhibit many more different half lives over a time period in either direction. Medknow Publications 1982 /pmc/articles/PMC3012879/ /pubmed/21965881 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pradhan, N.
Devi, K. Uma
Channabasavanna, S.M.
Subhash, M.
Rama Rao, B. S. Sridhara
A BI-COMPARTMENTL MODEL SYSTEM FOR LITHIUM KINETICS IN MANIA
title A BI-COMPARTMENTL MODEL SYSTEM FOR LITHIUM KINETICS IN MANIA
title_full A BI-COMPARTMENTL MODEL SYSTEM FOR LITHIUM KINETICS IN MANIA
title_fullStr A BI-COMPARTMENTL MODEL SYSTEM FOR LITHIUM KINETICS IN MANIA
title_full_unstemmed A BI-COMPARTMENTL MODEL SYSTEM FOR LITHIUM KINETICS IN MANIA
title_short A BI-COMPARTMENTL MODEL SYSTEM FOR LITHIUM KINETICS IN MANIA
title_sort bi-compartmentl model system for lithium kinetics in mania
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012879/
https://www.ncbi.nlm.nih.gov/pubmed/21965881
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