Cargando…

Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity

Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (htt) protein. To uncover candidate therapeutic targets and networks involved in pathogenesis, we integrated gene expression profiling and functional genetic screening to identi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tauber, Eran, Miller-Fleming, Leonor, Mason, Robert P., Kwan, Wanda, Clapp, Jannine, Butler, Nicola J., Outeiro, Tiago F., Muchowski, Paul J., Giorgini, Flaviano
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Genomics and Proteomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012999/ https://www.ncbi.nlm.nih.gov/pubmed/21044956 http://dx.doi.org/10.1074/jbc.M110.101527

Ejemplares similares

Visualization of cell-to-cell transmission of mutant huntingtin oligomers
por: Herrera, Federico, et al.
Publicado: (2011)

Aggregation-Prone Proteins Modulate Huntingtin Inclusion Body Formation in Yeast
por: Kantcheva, Ralitsa B., et al.
Publicado: (2014)

Genome-wide Analysis of Transcription Factor E2F1 Mutant Proteins Reveals That N- and C-terminal Protein Interaction Domains Do Not Participate in Targeting E2F1 to the Human Genome
por: Cao, Alina R., et al.
Publicado: (2011)

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane
por: Swaih, Aisha M., et al.
Publicado: (2022)

Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models
por: Pruccoli, Letizia, et al.
Publicado: (2021)

Connecting the dots in Huntington's disease with protein interaction networks
por: Giorgini, Flaviano, et al.
Publicado: (2005)

Combining RNA Interference Mutants and Comparative Proteomics to Identify Protein Components and Dependences in a Eukaryotic Flagellum
por: Portman, Neil, et al.
Publicado: (2009)

Genomotyping of Pseudomonas putida strains using P. putida KT2440-based high-density DNA microarrays: implications for transcriptomics studies
por: Ballerstedt, Hendrik, et al.
Publicado: (2007)

Proteomic Analysis of Native Hepatocyte Nuclear Factor-4α (HNF4α) Isoforms, Phosphorylation Status, and Interactive Cofactors
por: Daigo, Kenji, et al.
Publicado: (2011)

Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS
por: Morrison, Charlotte, et al.
Publicado: (2011)

Biochemical Characterization and N-terminomics Analysis of Leukolysin, the Membrane-type 6 Matrix Metalloprotease (MMP25): CHEMOKINE AND VIMENTIN CLEAVAGES ENHANCE CELL MIGRATION AND MACROPHAGE PHAGOCYTIC ACTIVITIES
por: Starr, Amanda E., et al.
Publicado: (2012)

Molecular Cloning and Characterization of First Organic Matrix Protein from Sclerites of Red Coral, Corallium rubrum
por: Debreuil, Julien, et al.
Publicado: (2012)

Dissecting the in Vivo Metabolic Potential of Two Human Gut Acetogens
por: Rey, Federico E., et al.
Publicado: (2010)

Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses
por: de Wet, Ben, et al.
Publicado: (2011)

Identification of New Substrates of the Protein-tyrosine Phosphatase PTP1B by Bayesian Integration of Proteome Evidence
por: Ferrari, Emanuela, et al.
Publicado: (2011)

Identification of Anhydrobiosis-related Genes from an Expressed Sequence Tag Database in the Cryptobiotic Midge Polypedilum vanderplanki (Diptera; Chironomidae)
por: Cornette, Richard, et al.
Publicado: (2010)

Novel Ubiquitin-derived High Affinity Binding Proteins with Tumor Targeting Properties
por: Lorey, Susan, et al.
Publicado: (2014)

Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation
por: Peffers, Mandy J., et al.
Publicado: (2014)

Interactome Analyses of Mature γ-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2
por: Jeon, Amy Hye Won, et al.
Publicado: (2013)

Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea
por: Ong, Ta-Hsuan, et al.
Publicado: (2016)

Identification and Pharmacological Inactivation of the MYCN Gene Network as a Therapeutic Strategy for Neuroblastic Tumor Cells
por: Chayka, Olesya, et al.
Publicado: (2015)

Discovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription
por: Hsiao, Jordy J., et al.
Publicado: (2016)

Stat3-mediated alterations in lysosomal membrane protein composition
por: Lloyd-Lewis, Bethan, et al.
Publicado: (2018)

SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics
por: Gupta, Ruchir, et al.
Publicado: (2020)

Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes
por: Perez, Vincent M., et al.
Publicado: (2020)

Identification of Burkholderia cenocepacia non-coding RNAs expressed during Caenorhabditis elegans infection
por: Pita, Tiago, et al.
Publicado: (2023)

Angiotensin-converting Enzyme Is a Modifier of Hypertensive End Organ Damage
por: Liu, Xiaojun, et al.
Publicado: (2009)

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species
por: Zhao, Yanding, et al.
Publicado: (2018)

Data on the aquaporin gene expression differences among ρ(0), clinically relevant radioresistant, and the parental cells of human cervical cancer and human tongue squamous cell carcinoma
por: Takashi, Yuko, et al.
Publicado: (2018)

Data-independent proteome analysis of ARPE-19 cells
por: Koirala, Diwa, et al.
Publicado: (2018)

Enzymatic synthesis of geranyl acetate in packed bed reactor in supercritical carbon dioxide under various pressure-temperature conditions and reactor configurations
por: Bourkaib, Mohamed Chafik, et al.
Publicado: (2018)

Data on tumor progression of c-mos deficiency in murine models of Kras(G12D) lung and Apc(Min) colorectal cancer
por: Chen, Zhengxi, et al.
Publicado: (2018)

A proteomic dataset of secreted proteins by three Staphylococcus saprophyticus strains
por: Oliveira, Andrea Santana de, et al.
Publicado: (2018)

Peptidome profiling dataset of ovarian cancer and non-cancer proximal fluids: Ascites and blood sera
por: Shender, Victoria, et al.
Publicado: (2018)

Data on proteomic profiling of cells and extracellular vesicles of the melittin-resistant Acholeplasma laidlawii strain
por: Medvedeva, E.S., et al.
Publicado: (2019)

Dataset of the frequency patterns of publications annotated to human protein-coding genes, their protein products and genetic relevance
por: Zwick, Matthias, et al.
Publicado: (2019)

Dataset on fat body proteome of Anopheles stephensi Liston
por: Kumar, Manish, et al.
Publicado: (2019)

Mass spectrometry data from identification of host-defense related proteins using label-free quantitative proteomic analysis of milk whey from cows with Staphylococcus aureus subclinical mastitis
por: Abdelmegid, Shaimaa, et al.
Publicado: (2019)

Outlining the Grb2 interactome data and its interacting partners in HEK293 cells in absence and presence of epidermal growth factor
por: Duggal, Shweta, et al.
Publicado: (2019)

High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
por: Gomig, Talita Helen Bombardelli, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jdtb8fes39b71t85i1lbqpbnhp