The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels

Autophagy degrades pathogens in vitro. The autophagy gene Atg5 has been reported to be required for IFN-γ-dependent host protection in vivo. However, these protective effects occur independently of autophagosome formation. Thus, the in vivo role of classic autophagy in protection conferred by adapti...

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Detalles Bibliográficos
Autores principales: Portillo, Jose-Andres C., Okenka, Genevieve, Reed, Erin, Subauste, Angela, Van Grol, Jennifer, Gentil, Katrin, Komatsu, Masaaki, Tanaka, Keiji, Landreth, Gary, Levine, Beth, Subauste, Carlos S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013095/
https://www.ncbi.nlm.nih.gov/pubmed/21217818
http://dx.doi.org/10.1371/journal.pone.0014472

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