Apoptosis of Purified CD4(+) T Cell Subsets Is Dominated by Cytokine Deprivation and Absence of Other Cells in New Onset Diabetic NOD Mice

BACKGROUND: Regulatory T cells (Treg) play a significant role in immune homeostasis and self-tolerance. Excessive sensitivity of isolated Treg to apoptosis has been demonstrated in NOD mice and humans suffering of type 1 diabetes, suggesting a possible role in the immune dysfunction that underlies a...

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Detalles Bibliográficos
Autores principales: Kaminitz, Ayelet, Askenasy, Enosh M., Yaniv, Isaac, Stein, Jerry, Askenasy, Nadir
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013115/
https://www.ncbi.nlm.nih.gov/pubmed/21209873
http://dx.doi.org/10.1371/journal.pone.0015684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013115/
https://www.ncbi.nlm.nih.gov/pubmed/21209873
http://dx.doi.org/10.1371/journal.pone.0015684

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