Increased Bone Marrow Interleukin-7 (IL-7)/IL-7R Levels but Reduced IL-7 Responsiveness in HIV-Positive Patients Lacking CD4+ Gain on Antiviral Therapy

BACKGROUND: The bone marrow (BM) cytokine milieu might substantially affect T-lymphocyte homeostasis in HIV-positive individuals. Interleukin-7 (IL-7) is a bone marrow-derived cytokine regulating T-cell homeostasis through a CD4+-driven feedback loop. CD4+ T-lymphopenia is associated with increased...

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Detalles Bibliográficos
Autores principales: Bellistrì, Giusi Maria, Casabianca, Anna, Merlini, Esther, Orlandi, Chiara, Ferrario, Giulio, Meroni, Luca, Galli, Massimo, Magnani, Mauro, Monforte, Antonella d'Arminio, Marchetti, Giulia
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013120/
https://www.ncbi.nlm.nih.gov/pubmed/21209878
http://dx.doi.org/10.1371/journal.pone.0015663

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