Nonsense Mediated Decay Resistant Mutations Are a Source of Expressed Mutant Proteins in Colon Cancer Cell Lines with Microsatellite Instability

BACKGROUND: Frameshift mutations in microsatellite instability high (MSI-High) colorectal cancers are a potential source of targetable neo-antigens. Many nonsense transcripts are subject to rapid degradation due to nonsense-mediated decay (NMD), but nonsense transcripts with a cMS in the last exon o...

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Detalles Bibliográficos
Autores principales: Williams, David S., Bird, Matthew J., Jorissen, Robert N., Yu, Yen Lin, Walker, Franscesa, Zhang, Hui Hua, Nice, Edouard C., Burgess, Antony W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013145/
https://www.ncbi.nlm.nih.gov/pubmed/21209843
http://dx.doi.org/10.1371/journal.pone.0016012

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