Cargando…

Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate

Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy. The present paper is focused on parallels between diab...

Descripción completa

Detalles Bibliográficos
Autores principales: Oelze, Matthias, Schuhmacher, Swenja, Daiber, Andreas
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014692/
https://www.ncbi.nlm.nih.gov/pubmed/21234399
http://dx.doi.org/10.1155/2010/213176
_version_ 1782195371609423872
author Oelze, Matthias
Schuhmacher, Swenja
Daiber, Andreas
author_facet Oelze, Matthias
Schuhmacher, Swenja
Daiber, Andreas
author_sort Oelze, Matthias
collection PubMed
description Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy. The present paper is focused on parallels between diabetes mellitus and nitrate tolerance, and aims to discuss the mechanisms underlying nitrate resistance in the setting of diabetes. Since oxidative stress was identified as an important factor in the development of tolerance to organic nitrates, but also represents a hallmark of diabetic complications, this may represent a common principle for both disorders where therapeutic intervention should start. This paper examines the evidence supporting the hypothesis that pentaerithrityl tetranitrate may represent a nitrate for treatment of ischemia in diabetic patients. This evidence is based on the considerations of parallels between diabetes mellitus and nitrate tolerance as well as on preliminary data from experimental diabetes studies.
format Text
id pubmed-3014692
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-30146922011-01-13 Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate Oelze, Matthias Schuhmacher, Swenja Daiber, Andreas Exp Diabetes Res Review Article Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy. The present paper is focused on parallels between diabetes mellitus and nitrate tolerance, and aims to discuss the mechanisms underlying nitrate resistance in the setting of diabetes. Since oxidative stress was identified as an important factor in the development of tolerance to organic nitrates, but also represents a hallmark of diabetic complications, this may represent a common principle for both disorders where therapeutic intervention should start. This paper examines the evidence supporting the hypothesis that pentaerithrityl tetranitrate may represent a nitrate for treatment of ischemia in diabetic patients. This evidence is based on the considerations of parallels between diabetes mellitus and nitrate tolerance as well as on preliminary data from experimental diabetes studies. Hindawi Publishing Corporation 2010 2010-12-27 /pmc/articles/PMC3014692/ /pubmed/21234399 http://dx.doi.org/10.1155/2010/213176 Text en Copyright © 2010 Matthias Oelze et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oelze, Matthias
Schuhmacher, Swenja
Daiber, Andreas
Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
title Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
title_full Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
title_fullStr Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
title_full_unstemmed Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
title_short Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
title_sort organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014692/
https://www.ncbi.nlm.nih.gov/pubmed/21234399
http://dx.doi.org/10.1155/2010/213176
work_keys_str_mv AT oelzematthias organicnitratesandnitrateresistanceindiabetestheroleofvasculardysfunctionandoxidativestresswithemphasisonantioxidantpropertiesofpentaerithrityltetranitrate
AT schuhmacherswenja organicnitratesandnitrateresistanceindiabetestheroleofvasculardysfunctionandoxidativestresswithemphasisonantioxidantpropertiesofpentaerithrityltetranitrate
AT daiberandreas organicnitratesandnitrateresistanceindiabetestheroleofvasculardysfunctionandoxidativestresswithemphasisonantioxidantpropertiesofpentaerithrityltetranitrate