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QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias?
Introduction. Several studies show that hypoglycemia causes QT interval prolongation. The aim of this study was to investigate the effect of QT measurement methodology, heart rate correction, and insulin types during hypoglycemia. Methods. Ten adult subjects with type 1 diabetes had hypoglycemia ind...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014697/ https://www.ncbi.nlm.nih.gov/pubmed/21234404 http://dx.doi.org/10.4061/2010/961290 |
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author | Christensen, Toke Folke Randløv, Jette Kristensen, Leif Engmann Eldrup, Ebbe Hejlesen, Ole Kristian Struijk, Johannes Jan |
author_facet | Christensen, Toke Folke Randløv, Jette Kristensen, Leif Engmann Eldrup, Ebbe Hejlesen, Ole Kristian Struijk, Johannes Jan |
author_sort | Christensen, Toke Folke |
collection | PubMed |
description | Introduction. Several studies show that hypoglycemia causes QT interval prolongation. The aim of this study was to investigate the effect of QT measurement methodology, heart rate correction, and insulin types during hypoglycemia. Methods. Ten adult subjects with type 1 diabetes had hypoglycemia induced by intravenous injection of two insulin types in a cross-over design. QT measurements were done using the slope-intersect (SI) and manual annotation (MA) methods. Heart rate correction was done using Bazett's (QTcB) and Fridericia's (QTcF) formulas. Results. The SI method showed significant prolongation at hypoglycemia for QTcB (42(6) ms; P < .001) and QTcF (35(6) ms; P < .001). The MA method showed prolongation at hypoglycemia for QTcB (7(2) ms, P < .05) but not QTcF. No difference in ECG variables between the types of insulin was observed. Discussion. The method for measuring the QT interval has a significant impact on the prolongation of QT during hypoglycemia. Heart rate correction may also influence the QT during hypoglycemia while the type of insulin is insignificant. Prolongation of QTc in this study did not reach pathologic values suggesting that QTc prolongation cannot fully explain the dead-in-bed syndrome. |
format | Text |
id | pubmed-3014697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-30146972011-01-13 QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias? Christensen, Toke Folke Randløv, Jette Kristensen, Leif Engmann Eldrup, Ebbe Hejlesen, Ole Kristian Struijk, Johannes Jan Cardiol Res Pract Research Article Introduction. Several studies show that hypoglycemia causes QT interval prolongation. The aim of this study was to investigate the effect of QT measurement methodology, heart rate correction, and insulin types during hypoglycemia. Methods. Ten adult subjects with type 1 diabetes had hypoglycemia induced by intravenous injection of two insulin types in a cross-over design. QT measurements were done using the slope-intersect (SI) and manual annotation (MA) methods. Heart rate correction was done using Bazett's (QTcB) and Fridericia's (QTcF) formulas. Results. The SI method showed significant prolongation at hypoglycemia for QTcB (42(6) ms; P < .001) and QTcF (35(6) ms; P < .001). The MA method showed prolongation at hypoglycemia for QTcB (7(2) ms, P < .05) but not QTcF. No difference in ECG variables between the types of insulin was observed. Discussion. The method for measuring the QT interval has a significant impact on the prolongation of QT during hypoglycemia. Heart rate correction may also influence the QT during hypoglycemia while the type of insulin is insignificant. Prolongation of QTc in this study did not reach pathologic values suggesting that QTc prolongation cannot fully explain the dead-in-bed syndrome. SAGE-Hindawi Access to Research 2010-12-22 /pmc/articles/PMC3014697/ /pubmed/21234404 http://dx.doi.org/10.4061/2010/961290 Text en Copyright © 2010 Toke Folke Christensen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Christensen, Toke Folke Randløv, Jette Kristensen, Leif Engmann Eldrup, Ebbe Hejlesen, Ole Kristian Struijk, Johannes Jan QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias? |
title | QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias? |
title_full | QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias? |
title_fullStr | QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias? |
title_full_unstemmed | QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias? |
title_short | QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias? |
title_sort | qt measurement and heart rate correction during hypoglycemia: is there a bias? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014697/ https://www.ncbi.nlm.nih.gov/pubmed/21234404 http://dx.doi.org/10.4061/2010/961290 |
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