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Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope

This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female Thomson's gazelle. Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fi...

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Autores principales: Gumber, Sanjeev, Lombardini, Eric, Williams, Bruce, Wakamatsu, Nobuko
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014702/
https://www.ncbi.nlm.nih.gov/pubmed/21234409
http://dx.doi.org/10.4061/2010/373698
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author Gumber, Sanjeev
Lombardini, Eric
Williams, Bruce
Wakamatsu, Nobuko
author_facet Gumber, Sanjeev
Lombardini, Eric
Williams, Bruce
Wakamatsu, Nobuko
author_sort Gumber, Sanjeev
collection PubMed
description This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female Thomson's gazelle. Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fine basophilic granules. Von Kossa staining showed the presence of calcium within cytoplasm, mainly in the inclusions, of hepatocytes. Transmission electron microscopy, scanning electron microscopy, energy dispersive X-rays analyses, and infrared spectroscopy on the liver showed the hepatocellular material consistent with protein and carbohydrate with secondary accumulation of calcium and phosphorus. It was concluded that crystalline inclusions may have been derived due to failure of normal physiological hepatocellular clearance associated with a severe chronic disease. To the authors' knowledge this is the first reported case of hepatocellular crystalline inclusions in an antelope.
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spelling pubmed-30147022011-01-13 Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope Gumber, Sanjeev Lombardini, Eric Williams, Bruce Wakamatsu, Nobuko Vet Med Int Case Report This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female Thomson's gazelle. Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fine basophilic granules. Von Kossa staining showed the presence of calcium within cytoplasm, mainly in the inclusions, of hepatocytes. Transmission electron microscopy, scanning electron microscopy, energy dispersive X-rays analyses, and infrared spectroscopy on the liver showed the hepatocellular material consistent with protein and carbohydrate with secondary accumulation of calcium and phosphorus. It was concluded that crystalline inclusions may have been derived due to failure of normal physiological hepatocellular clearance associated with a severe chronic disease. To the authors' knowledge this is the first reported case of hepatocellular crystalline inclusions in an antelope. SAGE-Hindawi Access to Research 2010-12-27 /pmc/articles/PMC3014702/ /pubmed/21234409 http://dx.doi.org/10.4061/2010/373698 Text en Copyright © 2010 Sanjeev Gumber et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gumber, Sanjeev
Lombardini, Eric
Williams, Bruce
Wakamatsu, Nobuko
Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope
title Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope
title_full Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope
title_fullStr Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope
title_full_unstemmed Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope
title_short Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope
title_sort intracytoplasmic crystalline inclusions in the hepatocytes of an antelope
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014702/
https://www.ncbi.nlm.nih.gov/pubmed/21234409
http://dx.doi.org/10.4061/2010/373698
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