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Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation

Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. D...

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Autores principales: Carrion, Andres F., Czul, Frank, Arosemena, Leopoldo R., Selvaggi, Gennaro, Garcia, Monica T., Tekin, Akin, Tzakis, Andreas G., Martin, Paul, Ghanta, Ravi K.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014703/
https://www.ncbi.nlm.nih.gov/pubmed/21234410
http://dx.doi.org/10.1155/2010/910636
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author Carrion, Andres F.
Czul, Frank
Arosemena, Leopoldo R.
Selvaggi, Gennaro
Garcia, Monica T.
Tekin, Akin
Tzakis, Andreas G.
Martin, Paul
Ghanta, Ravi K.
author_facet Carrion, Andres F.
Czul, Frank
Arosemena, Leopoldo R.
Selvaggi, Gennaro
Garcia, Monica T.
Tekin, Akin
Tzakis, Andreas G.
Martin, Paul
Ghanta, Ravi K.
author_sort Carrion, Andres F.
collection PubMed
description Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.
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spelling pubmed-30147032011-01-13 Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation Carrion, Andres F. Czul, Frank Arosemena, Leopoldo R. Selvaggi, Gennaro Garcia, Monica T. Tekin, Akin Tzakis, Andreas G. Martin, Paul Ghanta, Ravi K. Int J Endocrinol Case Report Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death. Hindawi Publishing Corporation 2010 2010-12-23 /pmc/articles/PMC3014703/ /pubmed/21234410 http://dx.doi.org/10.1155/2010/910636 Text en Copyright © 2010 Andres F. Carrion et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Carrion, Andres F.
Czul, Frank
Arosemena, Leopoldo R.
Selvaggi, Gennaro
Garcia, Monica T.
Tekin, Akin
Tzakis, Andreas G.
Martin, Paul
Ghanta, Ravi K.
Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation
title Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation
title_full Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation
title_fullStr Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation
title_full_unstemmed Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation
title_short Propylthiouracil-Induced Acute Liver Failure: Role of Liver Transplantation
title_sort propylthiouracil-induced acute liver failure: role of liver transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014703/
https://www.ncbi.nlm.nih.gov/pubmed/21234410
http://dx.doi.org/10.1155/2010/910636
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