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Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder

The authors report a case showing proliferation of KIT- and connexin 43-expressing mesenchymal cells of the urinary bladder. A 75-year-old woman had an ulcerated endophytic mass (size, approximately 2 × 2 cm) in the left posterolateral wall. She underwent transurethral resection and subsequent parti...

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Autores principales: Takeuchi, Tamotsu, Tanimura, Masanobu, Shimamoto, Tsutomu, Yasuda, Masaharu, Furihata, Mutsuo
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014713/
https://www.ncbi.nlm.nih.gov/pubmed/21234420
http://dx.doi.org/10.4061/2010/961325
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author Takeuchi, Tamotsu
Tanimura, Masanobu
Shimamoto, Tsutomu
Yasuda, Masaharu
Furihata, Mutsuo
author_facet Takeuchi, Tamotsu
Tanimura, Masanobu
Shimamoto, Tsutomu
Yasuda, Masaharu
Furihata, Mutsuo
author_sort Takeuchi, Tamotsu
collection PubMed
description The authors report a case showing proliferation of KIT- and connexin 43-expressing mesenchymal cells of the urinary bladder. A 75-year-old woman had an ulcerated endophytic mass (size, approximately 2 × 2 cm) in the left posterolateral wall. She underwent transurethral resection and subsequent partial cystectomy. The suburothelial mass extended to the muscularis propria. The histopathological analysis revealed spindle-shaped mesenchymal cells that were loosely arranged with myxoid stroma and showed a focal compact fascicular arrangement. In the immunohistochemical analysis, these spindle cells were stained with specific antibodies to KIT and connexin 43. The patient is currently free of disease at 5 years after operation. The proliferating spindle cells in the present case might represent a phenotype of interstitial cells of the lamina propria.
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spelling pubmed-30147132011-01-13 Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder Takeuchi, Tamotsu Tanimura, Masanobu Shimamoto, Tsutomu Yasuda, Masaharu Furihata, Mutsuo Patholog Res Int Case Report The authors report a case showing proliferation of KIT- and connexin 43-expressing mesenchymal cells of the urinary bladder. A 75-year-old woman had an ulcerated endophytic mass (size, approximately 2 × 2 cm) in the left posterolateral wall. She underwent transurethral resection and subsequent partial cystectomy. The suburothelial mass extended to the muscularis propria. The histopathological analysis revealed spindle-shaped mesenchymal cells that were loosely arranged with myxoid stroma and showed a focal compact fascicular arrangement. In the immunohistochemical analysis, these spindle cells were stained with specific antibodies to KIT and connexin 43. The patient is currently free of disease at 5 years after operation. The proliferating spindle cells in the present case might represent a phenotype of interstitial cells of the lamina propria. SAGE-Hindawi Access to Research 2010-12-22 /pmc/articles/PMC3014713/ /pubmed/21234420 http://dx.doi.org/10.4061/2010/961325 Text en Copyright © 2010 Tamotsu Takeuchi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Takeuchi, Tamotsu
Tanimura, Masanobu
Shimamoto, Tsutomu
Yasuda, Masaharu
Furihata, Mutsuo
Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder
title Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder
title_full Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder
title_fullStr Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder
title_full_unstemmed Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder
title_short Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder
title_sort pseudosarcomatous proliferation of cx43- and kit-expressing interstitial cell in the urinary bladder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014713/
https://www.ncbi.nlm.nih.gov/pubmed/21234420
http://dx.doi.org/10.4061/2010/961325
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