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Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas
Rodents move their whiskers to locate and identify objects. Cortical areas involved in vibrissal somatosensation and sensorimotor integration include the vibrissal area of the primary motor cortex (vM1), primary somatosensory cortex (vS1; barrel cortex), and secondary somatosensory cortex (S2). We m...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014926/ https://www.ncbi.nlm.nih.gov/pubmed/21245906 http://dx.doi.org/10.1371/journal.pbio.1000572 |
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author | Hooks, B. M. Hires, S. Andrew Zhang, Ying-Xin Huber, Daniel Petreanu, Leopoldo Svoboda, Karel Shepherd, Gordon M. G. |
author_facet | Hooks, B. M. Hires, S. Andrew Zhang, Ying-Xin Huber, Daniel Petreanu, Leopoldo Svoboda, Karel Shepherd, Gordon M. G. |
author_sort | Hooks, B. M. |
collection | PubMed |
description | Rodents move their whiskers to locate and identify objects. Cortical areas involved in vibrissal somatosensation and sensorimotor integration include the vibrissal area of the primary motor cortex (vM1), primary somatosensory cortex (vS1; barrel cortex), and secondary somatosensory cortex (S2). We mapped local excitatory pathways in each area across all cortical layers using glutamate uncaging and laser scanning photostimulation. We analyzed these maps to derive laminar connectivity matrices describing the average strengths of pathways between individual neurons in different layers and between entire cortical layers. In vM1, the strongest projection was L2/3→L5. In vS1, strong projections were L2/3→L5 and L4→L3. L6 input and output were weak in both areas. In S2, L2/3→L5 exceeded the strength of the ascending L4→L3 projection, and local input to L6 was prominent. The most conserved pathways were L2/3→L5, and the most variable were L4→L2/3 and pathways involving L6. Local excitatory circuits in different cortical areas are organized around a prominent descending pathway from L2/3→L5, suggesting that sensory cortices are elaborations on a basic motor cortex-like plan. |
format | Text |
id | pubmed-3014926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30149262011-01-18 Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas Hooks, B. M. Hires, S. Andrew Zhang, Ying-Xin Huber, Daniel Petreanu, Leopoldo Svoboda, Karel Shepherd, Gordon M. G. PLoS Biol Research Article Rodents move their whiskers to locate and identify objects. Cortical areas involved in vibrissal somatosensation and sensorimotor integration include the vibrissal area of the primary motor cortex (vM1), primary somatosensory cortex (vS1; barrel cortex), and secondary somatosensory cortex (S2). We mapped local excitatory pathways in each area across all cortical layers using glutamate uncaging and laser scanning photostimulation. We analyzed these maps to derive laminar connectivity matrices describing the average strengths of pathways between individual neurons in different layers and between entire cortical layers. In vM1, the strongest projection was L2/3→L5. In vS1, strong projections were L2/3→L5 and L4→L3. L6 input and output were weak in both areas. In S2, L2/3→L5 exceeded the strength of the ascending L4→L3 projection, and local input to L6 was prominent. The most conserved pathways were L2/3→L5, and the most variable were L4→L2/3 and pathways involving L6. Local excitatory circuits in different cortical areas are organized around a prominent descending pathway from L2/3→L5, suggesting that sensory cortices are elaborations on a basic motor cortex-like plan. Public Library of Science 2011-01-04 /pmc/articles/PMC3014926/ /pubmed/21245906 http://dx.doi.org/10.1371/journal.pbio.1000572 Text en Hooks et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hooks, B. M. Hires, S. Andrew Zhang, Ying-Xin Huber, Daniel Petreanu, Leopoldo Svoboda, Karel Shepherd, Gordon M. G. Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas |
title | Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas |
title_full | Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas |
title_fullStr | Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas |
title_full_unstemmed | Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas |
title_short | Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas |
title_sort | laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014926/ https://www.ncbi.nlm.nih.gov/pubmed/21245906 http://dx.doi.org/10.1371/journal.pbio.1000572 |
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