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Systems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase

BACKGROUND: The biotechnology industry has extensively exploited Escherichia coli for producing recombinant proteins, biofuels etc. However, high growth rate aerobic E. coli cultivations are accompanied by acetate excretion i.e. overflow metabolism which is harmful as it inhibits growth, diverts val...

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Detalles Bibliográficos
Autores principales:	Valgepea, Kaspar, Adamberg, Kaarel, Nahku, Ranno, Lahtvee, Petri-Jaan, Arike, Liisa, Vilu, Raivo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014970/ https://www.ncbi.nlm.nih.gov/pubmed/21122111 http://dx.doi.org/10.1186/1752-0509-4-166

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