Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease

A means for measuring levels of soluble huntingtin proteins in clinical samples is essential for assessing the biological effects of potential mutant huntingtin (mtHtt) modifying treatments being developed for Huntington’s disease (HD). We have optimized a previously described cell-based Homogeneous...

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Detalles Bibliográficos
Autores principales: Moscovitch-Lopatin, Miriam, Weiss, Andreas, Rosas, Herminia Diana, Ritch, James, Doros, Gheorghe, Kegel, Kimberly B., Difiglia, Marian, Kuhn, Rainer, Bilbe, Graeme, Paganetti, Paolo, Hersch, Steven
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015780/
https://www.ncbi.nlm.nih.gov/pubmed/21278900
http://dx.doi.org/10.1371/currents.RRN1205

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