Cell cyclins: triggering elements of cancer or not?

Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and espec...

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Detalles Bibliográficos
Autores principales: Stamatakos, Michael, Palla, Victoria, Karaiskos, Ioannis, Xiromeritis, Konstantinos, Alexiou, Ioannis, Pateras, Ioannis, Kontzoglou, Konstantinos
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016250/
https://www.ncbi.nlm.nih.gov/pubmed/21176227
http://dx.doi.org/10.1186/1477-7819-8-111
Descripción
Sumario:Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy.

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