Cell cyclins: triggering elements of cancer or not?

Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and espec...

Descripción completa

Detalles Bibliográficos
Autores principales: Stamatakos, Michael, Palla, Victoria, Karaiskos, Ioannis, Xiromeritis, Konstantinos, Alexiou, Ioannis, Pateras, Ioannis, Kontzoglou, Konstantinos
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016250/
https://www.ncbi.nlm.nih.gov/pubmed/21176227
http://dx.doi.org/10.1186/1477-7819-8-111
_version_ 1782195701471510528
author Stamatakos, Michael
Palla, Victoria
Karaiskos, Ioannis
Xiromeritis, Konstantinos
Alexiou, Ioannis
Pateras, Ioannis
Kontzoglou, Konstantinos
author_facet Stamatakos, Michael
Palla, Victoria
Karaiskos, Ioannis
Xiromeritis, Konstantinos
Alexiou, Ioannis
Pateras, Ioannis
Kontzoglou, Konstantinos
author_sort Stamatakos, Michael
collection PubMed
description Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy.
format Text
id pubmed-3016250
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-30162502011-01-06 Cell cyclins: triggering elements of cancer or not? Stamatakos, Michael Palla, Victoria Karaiskos, Ioannis Xiromeritis, Konstantinos Alexiou, Ioannis Pateras, Ioannis Kontzoglou, Konstantinos World J Surg Oncol Review Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy. BioMed Central 2010-12-22 /pmc/articles/PMC3016250/ /pubmed/21176227 http://dx.doi.org/10.1186/1477-7819-8-111 Text en Copyright ©2010 Stamatakos et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Stamatakos, Michael
Palla, Victoria
Karaiskos, Ioannis
Xiromeritis, Konstantinos
Alexiou, Ioannis
Pateras, Ioannis
Kontzoglou, Konstantinos
Cell cyclins: triggering elements of cancer or not?
title Cell cyclins: triggering elements of cancer or not?
title_full Cell cyclins: triggering elements of cancer or not?
title_fullStr Cell cyclins: triggering elements of cancer or not?
title_full_unstemmed Cell cyclins: triggering elements of cancer or not?
title_short Cell cyclins: triggering elements of cancer or not?
title_sort cell cyclins: triggering elements of cancer or not?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016250/
https://www.ncbi.nlm.nih.gov/pubmed/21176227
http://dx.doi.org/10.1186/1477-7819-8-111
work_keys_str_mv AT stamatakosmichael cellcyclinstriggeringelementsofcancerornot
AT pallavictoria cellcyclinstriggeringelementsofcancerornot
AT karaiskosioannis cellcyclinstriggeringelementsofcancerornot
AT xiromeritiskonstantinos cellcyclinstriggeringelementsofcancerornot
AT alexiouioannis cellcyclinstriggeringelementsofcancerornot
AT paterasioannis cellcyclinstriggeringelementsofcancerornot
AT kontzogloukonstantinos cellcyclinstriggeringelementsofcancerornot

Ejemplares similares