Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures

BACKGROUND: Hedgehog (HH) signaling is critical for the expansion of granule neuron precursors (GNPs) within the external granular layer (EGL) during cerebellar development. Aberrant HH signaling within GNPs is thought to give rise to medulloblastoma (MB) - the most commonly-observed form of maligna...

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Detalles Bibliográficos
Autores principales: Cohen, Joseph R, Resnick, Daniel Z, Niewiadomski, Pawel, Dong, Hongmei, Liau, Linda M, Waschek, James A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016295/
https://www.ncbi.nlm.nih.gov/pubmed/21143927
http://dx.doi.org/10.1186/1471-2407-10-676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016295/
https://www.ncbi.nlm.nih.gov/pubmed/21143927
http://dx.doi.org/10.1186/1471-2407-10-676

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