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Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models
Neuroprotectin D1 (NPD1) is a stereoselective mediator derived from the omega-3 essential fatty acid docosahexaenoic acid (DHA) with potent inflammatory resolving and neuroprotective bioactivity. NPD1 reduces Aβ42 peptide release from aging human brain cells and is severely depleted in Alzheimer...
Autores principales: | Zhao, Yuhai, Calon, Frederic, Julien, Carl, Winkler, Jeremy W., Petasis, Nicos A., Lukiw, Walter J., Bazan, Nicolas G. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016440/ https://www.ncbi.nlm.nih.gov/pubmed/21246057 http://dx.doi.org/10.1371/journal.pone.0015816 |
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